Chapter 2 - Immunity and the Non-specific Immune System Flashcards

1
Q
  1. Best examples of natural passive VS natural active immunity
A

PLACENTAL TRANSFER AND RECOVERY

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2
Q
  1. Best examples of artificial passive VS artificial active immunity
A

ANTIBODY/ANTITOXIN ADMINISTRATION and VACCINATION (ANTIGENIC STIMULATION)

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3
Q
  1. Ingestion of particulate matter such as bacteria by a cell
A

PHAGOCYTOSIS

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4
Q
  1. Internalization of fluids and solutes by a cell
A

PINOCYTOSIS

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5
Q
  1. Name the tissue macrophages of the ff: liver, connective tissue, kidney, brain, joints, lungs, epidermis
A

KUPFFER, HISTIOCYTES, MESANGIAL, MICROGLIAL, SYNOVIAL ‘A’, ALVEOLAR, LANGERHANS

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6
Q
  1. Cell surface receptors important for the attachment of pathogens in phagocytosis
A
  • FORMYL-METHIONYL-LEUCYL-PHENYLALANINE (FMLP) RECEPTOR

- CR3 RECEPTOR, - - LAMININ RECEPTOR

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7
Q
  1. Other term of “digestion” by phagocytes
A

CYTOPEPSIS

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8
Q
  1. Cell surface proteins that promote cell-to-cell interaction to enhance phagocytosis
A

INTEGRINS

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9
Q
  1. Substances that coat particles and other organisms making them more susceptible to phagocytosis
A

OPSONINS

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10
Q
  1. An opsonin that acts like a glue to cause neutrophils and their targets to stick together
A

FIBRONECTIN

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11
Q
  1. An opsonin that enhances the interaction of phagocytes and antibody-coated particle
A

CRYSTALLIZABLE FRAGMENT (Fc) OF IMMUNOGLOBULIN

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12
Q
  1. The 5 cardinals of inflammation
A
RUBOR
TUMOR
COLOR 
DOLOR 
FUNCTIO LAESA
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13
Q
  1. Stages of inflammation
A

VASCULAR RESPONSE, CELLULAR RESPONSE, CELLULAR PROLIFERATION AND REPAIR

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14
Q
  1. Complement split product that functions as chemoattractant for phagocytes
A

C5a

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15
Q
  1. Identify the type I and II interferons and their origin
A

Type I:
> IFN-alpha (MACROPHAGES and OTHER LEUKOCYTES)
> IFN-beta (FIBROBLASTS);

Type II:
> IFN-gamma/immune IFN (T-CELLS)

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16
Q
  1. An AA released by ruptured platelets which are directed as cationic detergent against gram-pos bacteria
A

BETA LYSINE

17
Q
  1. Two iron storage proteins that competes bacteria for iron
A

LACTOFERRIN & TRANSFERRIN

18
Q
  1. Enzyme found in milk and saliva that catalyzes the conversion of hydrogen peroxide to water and oxygen
A

LACTOPEROXIDASE

19
Q
  1. Enzyme that hydrolyzes the mucopeptide layer of the bacterial cell wall leading to osmotic lysis
A

LYSOZYME

20
Q
  1. Composition of NK cells in the peripheral blood
A

10-15%

21
Q
  1. NK cells are absent in what lymphoid organ
A

LYMPH NODES

22
Q
  1. Pore-forming protein released by CTLs and NK cells
A

PERFORIN

23
Q
  1. Subset of killer cells that can lyse target cells coated with antibodies w/o the participation of complement
A

ANTIBODY-DEPENDENT CYTOTOXIC CELLS (ADCC)

24
Q
  1. CD marker for ADCC
A

CD16

25
Q
  1. Lymphocyte induced into cytotoxic state by IL-2
A

LYMPHOKINE-ACTIVATED KILLER CELL (LAK)

26
Q
  1. Tumor-specific t-cells and have tumoricidal activity
A

TUMOR INFLITRATING LYMPHOCYTE (TIL)