Chapter 5: Drug References

Question 1

Definition: package insert

Answer 1

FDA approved drug information. Only contains iformation approved by FDA

does not include off label uses or cost

Question 2

Definition: Boxed Warnings

Answer 2

• the strictest warnning
• alerts prescribers of risk of death or permanent disability

Question 3

Definition: contraindications

Answer 3

• if a pt has a contraindication, the drug canNOT be used in taht patient
• risk outweights possible benefit

Question 4

Definition: warnings and precautions

Answer 4

include serious reactions that can result ind eath, hospitalziation, medical intervention, disability or teratogenicity

Question 5

Definition: adverse reactiosn

Answer 5

refers to undesirable, uncomfortable or dangerous effects

Question 6

Labeling requirements for OTC

Answer 6

• active ingredients
• uses for the product
• speific warnings, including when the drug should NOT be used
• side effects
• dosage insturctions
• inactive ingredients

Question 7

Anticoagulation guidelines

Answer 7

Guidelines from the American College of Chest Physicians (CHEST guidelines)

A. fib, VTE

Question 8

Cardiovascular disease guidelines

Answer 8

Guidelines from the American College of Cardiology/American Heart Association (ACC/AHA)

• ACS
• A. fib
• HF
• High cholesterol
• HTN

Question 9

Diabetes guideliens

Answer 9

• American Association of Clinical Endocrinologists (AACE)
• American Diabetes Association (ADA)

Question 10

Infectious disase guidelines

Answer 10

• Infetious Diseases Society of America (IDSA)
• HIV/AIDS: US Dept of Health and Human Services (clincalinfo.hiv.gov)
• Sexually Transmitted Infections: Centers for Disease Control (CDC)

Sanford Guide to Antimicrobial Therapy (Reference)

Question 11

Oncology guideliens

Answer 11

• American Society of Clinical Oncology (ASCO)
• National Comprehensive Cancer Network (NCCN)

Question 12

Pediatrics guidelines

Answer 12

The American Academy of Pediatrics (AAP)

References:
- NeoFax and Pediatrics
- Pediatric & Neonatal Lexi-drugs
- Red Book
- Harriet Lane Handbook
- KIDS List (PIM’s for kids)

Question 13

Pregnancy/Women’s Health guidelins

Answer 13

The American COllege of Obstetricians and Gyenocologists (ACOG)

References
- Briggs’ Drugs in Pregnagny and Lactation
- CDC
- Hale’s Medications and Mother’s Milk
- LactMed

Question 14

Psychiatric conditions guideliens

Answer 14

• AMerican Psychiatric Association (APA) Diagnositc and Statistical Manual of Mental disorders (DSM)

Question 15

Pulmonary conditions guidelines

Answer 15

• Asthma: Global Initiative for Asthma (GINA)
• COPD: Global Initiative for COPD (GOLD)

Question 16

Kidney diseases guidelines

Answer 16

KDIGO

Question 17

Vaccines guidelines

Answer 17

• Advisory Committee on Immunization Practices (ACIP) - updates published in the Morbidity and Mortality Weekly Report (MMWR)
• Centers for DIsease Control (CDC)

Question 18

FDAble

Answer 18

FDA serachable database of ADR caused by medicines, vaccines, devices, tobacco products, and dietary supplements

• MedWatch: FDA’s Adverse Event Reporting System (FAERS)
• Vaccine Adverse Event Reporting SYstem (VAERS)

Question 19

Compounding references

Answer 19

• Allen’s The Art, Science, and Technology of Pharmaceutical Compounding
• Safety Data Sheets
• USP 795: non-sterile
• USP 797: Sterile
• USP 800: Hazardous
• USP NF: monographs for drug sustances, dosage forms, compounded preparations and expients

Question 19

Merck Index

Answer 19

databsase of monographs for chemicals, drugs, adn biologicals

Question 20

RED BOOK

Answer 20

micromedex resource on drug priceing

Question 21

where to look for information on drug shortges

Answer 21

• ASHP current drug shortages
• FDA drug shortages

Question 22

reference for med use in geriatrcs

Answer 22

American Geriatric Society (AGS) Beers Criteria

Question 23

CDC Pink Book

Answer 23

epidemiology and prevention of vaccine preventable disases

Question 24

Where to find international drug information

Answer 24

- Index Nomium: international drug directory - Martindale: the complete drug referece

Question 25

where to find investigational drugs

Answer 25

clinicaltrials.gov

Question 26

reference for IV drug compatibility and stability

Answer 26

- ASHP Handbook on Injectable Drugs - King Guide to Parenteral Admixtures - Trissel's 2 CLinical Pharmaceutics Database

Question 27

Where to report med errors

Answer 27

Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program)

Question 28

NIOSH

Answer 28

list of antineoplastic and other hazardous drugs

Question 29

Reference for natural products and alternative medicine

Answer 29

NatMed

Question 30

reference for pharmacology

Answer 30

Goodman and Gilman's The Pharmacological Basis of Therapeutics

Question 31

reference fo poisoning and toxicology

Answer 31

- Lexi-Tox - Micromedex

Question 32

veterinary reference

Answer 32

Plumb's

Question 33

"color" drug references

Answer 33

- Red Book, Pharmacy: drug pricing - Red Book, Pediatrics: summaries of peds ID, ABX, and vaccine info - Orange Book (FDA): approved drugs that can be interchaged with generics - Yellow Book (CDC): info on interational travel, vaccines, and ppx - Green Book (FDA): info on approved annimal drug products - Purple Book (FDA): list of biologicals and biosimilars - Pink Book (CDCC): epidemiology and vaccine preventable diseases - Pink Sheet (Pharma Intelligence): news reports on regulatory, legislative, legal and business developments

Question 34

Consumer resources

Answer 34

- CDC: ID, immunizations, and travel - Drugs.com and RxList - Mayo Clinic - Medline Plus - WebMD: has pill identifier and interaction checker