Chapter 5 - Catecholamines Flashcards
What NTs fall under Catecholamines?
Dopamine (DA), Norepinephrine (NE), Epinephrine
What are NE, DA, and EPI made from?
Tyrosine
Tyrosine is converted into ______ by _______. What is important about this step?
L-DOPA by tyrosine hydroxylase. It is a rate limiting step.
What is the process from tyrosine to EPI?
Tyrosine > L-DOPA > Dopamine > NE > EPI
In the process from tyrosine to EPI what are the enzymes involved?
tyrosine hydroxlase > Aromatic amino acid decarboxlase > Dopamine B-hydroxylase.
Think of it as TH > A > B
In animal models, what stereotyped behaviours are present with higher DA?
IRL
- Intense sniffing
- Repetitive head and limb movements,
- Licking and biting
DA gets packaged into what specific transporter?
A monoamine specific transporter. more specifically a VMAT (Vesicular Monoamine Transporter)
The VMAT is? What drug blocks this?
Vesicular Monoamine Transporter.
Reserpine
Why is it important to package DA in vesicles?
Otherwise it will be broken down quickly in cytoplasm
How do vesicles get released?
By exocytosis with Action Potentials
Which drugs release without cell firing?
(Meth)amphetamines.
Synaptic release occurs by _______ located on:
a. )___________
b. )___________
c. )___________
Autoreceptors located on
- cell bodies
- terminals
- dendrites
DA is produced in which 2 areas?
Mesostriatal/Nigrostriatal
and
Mesolimbocortical
DA in Mesostriatal/Nigrostriatal helps with what?
Facilitating voluntary body movements.
A loss in DA in mesocortical/nigrostriatal is associated with what?
Parkinsons Disease
