Chapter 5-2

Question 1

Anemia of Chronic Dz

Answer 1

Increase acute phase reactant ie Hepcidin

Question 2

Hepcidin

Answer 2

Body thinks microbe causing chronic Inflam= Sequester all Fe into MPs, block EPO. Block Fe develop MICROCYTIC anemia

Question 3

labs for Anemia of chronic Dz

Answer 3

increase Ferritin & FEP, dec TIBC serum Fe, dec %sat

Question 4

Sideroblastic anemia

Answer 4

defect in heme’s PROTOPORPHYRIN. Microcytic anemia

Question 5

RLE in Protoporphyrin synthesis, Cofactor?

Answer 5

succinyl CoA To Aminovulinic acid via Aminolevulinic Acid Synthetase needs Vitamin B6

Question 6

last step to make heme Enzyme and location

Answer 6

Ferrochelatase attaches protoporphyrin to Fe=Heme In the Mitochondria of erythroid precursor

Question 7

If Protoporphryin def.

Answer 7

iron laded Mitochondria= ringed sideroblast

Question 8

most common cause of congenital sideroblastic anemia

Answer 8

ALAS RLE for protoporphyrin synthesis

Question 9

Acquired causes of sideroblastic anemia

Answer 9

Alcoholism- mito. poison
Lead poison- inibits ALAD and Ferrochelatase
Vit B6 def- cofactor of ALAS most commonly seen as SI of TB tx with isoniazid

Question 10

pt on TB tx with isoniazid at risk for which anemia?

Answer 10

sideroblastic anemia def in cofactor B6 cant do RLE step with VitB6

Question 11

lab findings for Sideroblastic anemia

Answer 11

dec. globin, dec hemoglobin, microcytic anemia-

Question 12

carries of Thalassemis inherited protect against?

Answer 12

plasmodium flaciparum.