Chapter 4 Nucleosides/Nucleotides (NEED TO KNOW) Flashcards
Nucleosides have a _____ and a ______
Nitrogenous base and a ribose sugar
Nucleotides are simply a ______ with one or more ____ attached
Nucleoside; phosphate groups
What is Adenine composed of?
A nitrogenous base
What is Adenosine composed of?
A nitrogenous base with a ribose sugar
What is adenosine-5-monophosphate composed of?
A Nitrogenous base, a ribose sugar, and a high energy phosphate bond
What is adenosine-5-diphosphate composed of?
A Nitrogenous base, a ribose sugar, and a high energy diphosphate bond
What is adenosine-5-triphosphate composed of?
A Nitrogenous base, a ribose sugar, and a high energy triphosphate bond
Adenine is also known as a_____
Purine base
Adenosine is also known as a ______
Nucleoside
Adenosine-5-monophosphate is also known as a _____
Nucleotide
Adenosine-5-diphosphate is also known as a _____
Nucleotide
Adenosine-5-triphosphate is also known as a _____
Nucleotide
Identify this sturcture
Adenine
Identify this structure
Guanine
Identify this structure
Cytosine
Identify this structure
Uracil
Identify this structure
Thymine
What is a required coenzyme for nucleoside/nucleotide synthesis and repair of DNA?
Folic Acid
What is a required coenzyme for methylation reactions?
Folic Acid
What is a required coenzyme for replication and growth of RBC?
Folic Acid
In the pyrimidine synthesis in DNA, what is folic acid utilized for?
To methylate the dUMP (deoxy uracil monophosphate)
Where is Folic acid important in pyrimidine synthesis?
The dUMP of DNA
What is a pyrimidine analogue of dUMP, and blocks production of dTDP?
Gluorodeoxyuridine (FdUMP)
What can be used as an antibiotic because it is converted into an active “nuceloside or nucleotide” only in bacteria?
Fluorocyotsine
What are the two chemotherapy agents which act by blocking folate addition to purine rings?
Aminopterin & Methotrexate
What is the primary cause of hyperuricenmia?
Renal underexcretion of uric acid
