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Phardose > Chapter 4 Lec > Flashcards

Chapter 4 Lec Flashcards

1
Q

all components natural

No components derived from ABC

A

Natural flavor, ABC type

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2
Q

Most frequently encountered destructive process

A

Hydrolysis and oxidation

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4
Q

Most desirable and convenient in oral and systemic use

A

Tablets and capsules

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6
Q

Molecules or atoms containing one or more unpaired electrons such a O2 and free OH

A

Free chemical radicals

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7
Q

Collection of basic info on the physical and chemical characteristics of drugs

A

Pre formulation studies

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8
Q

Formulation that best meets the goals for the product

A

Master formula

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9
Q

Relate its ability to get to a site of action and elicit biological response

A

Biologic properties

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10
Q

Determine the purity of drug

A

Melting point depression

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11
Q

Characteristic of each solid compound and a given solvent in a fixed experimental condition

A

Intrinsic dissolution rate

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13
Q

Constructed to provide a visual picture of solid and liquid phases

A

Phase diagram

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14
Q

Rate which a drug becomes available to the organism

Rate limiting step

A

Dissolution

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16
Q

Passage of drug molecules across biologic membranes

A

Membrane permeability

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17
Q

Suspension id added to a fixed amt of solvent w/o extract control of surface area

A

Particulate dissolution

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18
Q

Process in which drug molecules interact w water molecules to yield breakdown products

A

Hydrolysis

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19
Q

Techniques to determine crystals

A

Hot stage microscopy
Thermal analysis
Infrared spectroscopy
X-ray diffraction

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20
Q

Used to aid in providing a global taste fingerprint

Provides info on bitterness levels and stability of flavors

A

Electronic tongue

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21
Q

Loss of electrons from atoms or molecules

A

Oxidation

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22
Q

High molecular weights are…

A

Bitter

23
Q

May contain artifical flavors

No reference point

A

Conceptual flavors

25
Q

Extent of dissociation or ionization of drug substances

A

Pka or dissociation constants

26
Q

Extent to which a product retains within specified limits

A

Stability

27
Q

2 methods to determine dissolution

A

Constant surface method

Particulate dissolution

28
Q

Lets the pharmacist estimate shelf life

A

Q10 method

30
Q

Low molecular weight salts are..

A

Salty

31
Q

All components natural

Atleast one component derived from ABC

A

ABC Flavor, WONP

32
Q

Pharmacopeias w the largest international use

A

USP
british
European
Jap

33
Q

Increase in hydroxyl groups…

A

Increase sweetness

34
Q

Easily swallowed w no contact between drug and tastebuss

A

Capsules and coated tablets

35
Q

Extremely butter (quinine)

A

Nitrogen containing compounds

36
Q

Description of the drug concentration w respect to the thme

A

Reaction rate

37
Q

N-methyl saccharin

A

Tasteless

39
Q

All components artificial

A

ABC flavor, artificial

40
Q

Aspartame

A

Sweet

Nitrogen containing compound

41
Q

Types of flavors

A

Natural, artificial and spice

42
Q

D-glucose

A

Sweet

44
Q

All components derived from ABC

A

Natural ABC flavor

46
Q

Atleast one component and artificially derived from ABC

A

ABC flavor, natural

47
Q

Saccharin

A

Very sweet

49
Q

Amount of heat absorbed when 1g of liq evaporates

A

Heat if vaporization

51
Q

Time taken for the radioactivity of a specified isotope to fall to half of its original value

A

Half life

52
Q

L glucose

A

Salty

58
Q

Structure, form and reactivity

A

Chemical properties

62
Q

Types of stability

A 
Chemical
 physical 
microbiology
 therapeutic
 toxicologic
68
Q

Affects sedimentation rates and flow characteristics

A

Particle siE

Phardose (7 decks)

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