Chapter 4: Immunology Flashcards
Helper T cells (CD4)
- Release IL-2 (causes maturation of cytotoxic T cells)
- Release IL-4 (causes B-cell maturation into plasma cells)
- Involved in delayed-type hypersensitivity
IL-2: function
Causes maturation of cytotoxic T cells
IL-4: function
Causes B-cell maturation into plasma cells
Brings in inflammatory cells by chemokine secretion
Delayed-type hypersensitivity
Suppressor T cells (CD8)
Regulate CD4 and CD8 cells
Cytotoxic T cells (CD8)
Recognize and attack non-self-antigens attached to MHC class 1 receptors (e.g. viral gene productS)
Intradermal skin test (i.e., TB skin test): type of immunity
cell-mediated immunity
Infections associated with defects in cell-mediated immunity
Intracellular pathogens (TB, viruses)
MHC class 1 (A, B, C)
CD8 cell activation
- Present on all nucleated cells
- Single chain with 5 domains
- Target for cytotoxic T cells (binds T cell receptor)
MHC class II (DR, DP, and DQ)
CD4 cell activation
- Present on antigen-presenting cells (e.g., monocytes, dendrites)
- 2 chains with 4 domains each
- Activates helper T cells (binds T cell receptor)
- Stimulates antibody formation after interaction with B cell surface IgM
Mechanism of immune response to viral infection
Endogenous viral proteins are produced, are bound to class I MHC, go to cell surface, and are recognized by CD8 cytotoxic T cells
Mechanism of immune response to bacterial infection
Endocytosis, proteins get bound to Class II MHC molecules, go to cell surface, recognized by CD4 helper T cells -> B cells which have already bound to the antigen are then activated by the CD4 helper T cells; they then produce the antibody to that antigen and are transformed to plasma cells and memory B cells.
Natural Killer Cells
- Not restricted by MHC, do not require previous exposure, do not require antigen presentation
- Not considered T or B cells
- Recognize cells that lack self-MHC
- Part of the body’s natural immunosurveillance for cancer
Initial antibody made after exposure to antigen. It is the largest antibody, having 5 domains (10 binding sites)
IgM
Most abundant antibody in body.
Responsible for secondary immune response.
Can cross the placenta and provide protection in newborn period.
IgG.