Chapter 4 Flashcards
1
Q
high affinity drugs **
A
- easier to bind
- produce effects at low concentration
- lower doses
- most desirable for therapeutic effects
2
Q
low affinity drugs **
A
- slower to bind
- higher doses
- produce effects at high concentration
- most desirable for toxic side effects
3
Q
nicotine **
A
- increases ACh
- blocked by curate
4
Q
cocaine **
A
blocks dopamine
5
Q
benzodiazepines **
A
- valium, xanax, amaine, etc
- indirect agonists of GABA
- anxiety dissolving drugs
- sleep medications
6
Q
different ways that drugs can affect the synapse **
A
- antagonists: block or inhibit
- agonists: facilitate or increase
7
Q
DOPA
A
increases dopamine
8
Q
black widow spider **
A
agonist of ACh
9
Q
GABA **
A
- inhibitory
- hyperpolarizes (reduces) neurons
- regulates communication btw brain cells
10
Q
Glutamate **
A
- excitatory
- depolarizes neurons
- too much activity can induce excitotoxicity
- sends signals between nerve cells
- important for learning and memory
11
Q
Glutamte receptors **
A
- NMDA: ionotropic
- AMPA: ionotropic
- Kainate: ionotropic
- metabotropic glutamate receptors
12
Q
NMDA **
A
controls Ca++ channels and blocked by Mg2+ ions
13
Q
AMPA **
A
controls Na+ channels
14
Q
Kainate
A
controls Na+ channels, stimulated by Kainic acid
15
Q
metabotropic glutamate
A
sensitive to glutamate
