chapter 4-5

Question 1

what is the role of protein C and S

Answer 1

the inactivate factor 5 &8

Question 2

def. in protein C & S risk for?

Answer 2

warfarin skin necrosis- bc warfarin blocks epoxide reductase from activating VIT K(vit K activates 2,7,9,10 C &S)

Question 3

factor 5 Leiden

Answer 3

mutated Factor 5, results in inability to Deactivate protein C and S
MOST COMMON INHERITED CAUSE OF HYPERCOAGULABLE state

Question 4

prothrombin 20210A

Answer 4

inherited point mutation in prothrombin results in increase prothrombin and increased thrombin=thrombus formation

Question 5

Antithrombin 3 def

Answer 5

loss of protective benefits of AT3– cant inactivate thrombin thrombin and coag factors.

Question 6

labs of AT3 def.

Answer 6

PTT does not rise with standard heparin dosing. Normally heparin drugs activate AT3, high doses of heparin activate limited AT3 around and coumadin also given to maintain anticoagulated state.

Question 7

estrogen effect on coagulation factors?

Answer 7

increases production of coagulation factors- increases risk of thrombus