chapter 4-4

Question 1

most common location for Thrombis

Answer 1

DVT in leg below knee

Question 2

thrombosis premortem

Answer 2

lines of zahn and attachment to vessel wall

Question 3

virchows triad

Answer 3

disruption in blood flow, endo cell damage, hyercoaguable state.

Question 4

endothelial cells prevent thrombosis

Answer 4

1-block exposure to subendothelial collagen- activates 12- factor coagulation cascade
2- PGI2 and NO - vasodilate and inhib plt aggregation
3- secrete anti-thrombin 3 inactivates thrombin and coaguation factor
4-tPA-converts plasminogen to plasmin
5- secrete thrombomodulin

Question 5

tPA

Answer 5

converts plasminogen plasmin. Plasmin cleaves fibrin and serum fibrinogen, destroys coagulation factor, block plt aggregation

Question 6

thrombomodulin

Answer 6

redirects thrombin to activate protein C inactivates factor 5 & 8

Question 7

elevated homocysteine levels

Answer 7

increases risk of thrombosis result of vit B12 & folate def. The deficiency leads to decreased homocys conversion to methionine

Question 8

how does folate circulate in the blood

Answer 8

serum -methyl-THF. The methyl group gets transferred to Cobalamin so THF goes to DNA synthesis.

Question 9

Cystathionine beta synthase def.

Answer 9

high homocysteine levels with homocystinuria.

CBS- converts homocys to cystathionine

Question 10

s/s of Cystathionine beta synthase

Answer 10

vessel thrombosis mental retardation, lens dislocation and long slender fingers.