chapter 30 - week 2 Flashcards
total body water comopsition
Total body water
Composed of:
Intracellular fluid: 67%
Interstitial fluid: 25%
Plasma volume: 8%
60% of adult human body is water.
intravascular fluid
Fluid inside blood vessels
extravascular fluid
Fluid outside blood vessels
Lymph, cerebrospinal fluid
extravascular volume
Plasma
Interstitial fluid: fluid in space between cells, tissues, and organs
extracellular volume
Interstitial fluid
Intracellular fluid
what is the pressure that plasma proteins exert
contstant osmotic pressure
colloid osmotic pressure
normally 24 mm. Hg
what is the pressure interstitial fluid exerts
hydrostatic pressure
noramlly 17 mm Hg
crystalloids
- Solutions containing fluids and electrolytes that are normally found in the body
- Do not contain proteins (colloids)
- No risk for viral transmission, anaphylaxis, or alteration in coagulation profile
what are crsytalloids used for
- Better for treating dehydration rather than expanding plasma volume
Used as maintenance fluids to: - Compensate for insensible fluid losses
- Replace fluids
- Manage specific fluid and electrolyte disturbances
- Promote urinary flow
crystalloid types
- Normal saline (NS): 0.9% sodium chloride is isotonic; 0.45% “half-normal” is hypotonic)
- 3.3% dextrose and 0.3% NS (two thirds and one third) (isotonic)
- Hypertonic saline (3% sodium chloride)
- Lactated Ringer’s solution (isotonic)
- Dextrose 5% in water (D5W) (isotonic)
- D5W and 0.45% NS (hypertonic)
- Plasma-Lyte (isotonic)
crystalloi indictations
Indications include:
* Acute liver failure
* Acute nephrosis
* Adult respiratory distress syndrome
* Burns
* Cardiopulmonary bypass
* Hypoproteinemia
* Hemodialysis
* Deep vein thrombosis (reduction of risk)
* Shock
crystalloid adverse effects
- Adverse effects
- May cause edema, especially peripheral or pulmonary
- May dilute plasma proteins, reducing colloid oncotic pressure
- Effects may be short-lived
- Prolonged infusions may worsen alkalosis or acidosis
colloid
Protein substances
Increase colloid oncotic pressure
Move fluid from interstitial compartment to plasma compartment (when plasma protein levels are low)
* Albumin 5% and 25% (from human donors)
* Dextran 40 or 70 (available in sodium chloride and 5% dextrose)
* Hetastarch (synthetic)
colloid adverse effects
- Usually safe
- May cause altered coagulation, resulting in bleeding
- Have no clotting factors or oxygen-carrying capacity
- Rarely, dextran therapy causes anaphylaxis or kidney failure.
albumin
colloids:
Natural protein that is normally produced by the liver
Responsible for generating approximately 70% of colloid oncotic pressure
Sterile solution of serum albumin that is prepared from pooled blood, plasma, serum, or placentas obtained from healthy human donors
Pasteurized to destroy any contaminants