Chapter 3: Protein structure & Amino acids Flashcards
Nonpolar side chains are…
Hydrophobic: they do not interact with water
Proteins are
Polymers made of monomers
Monomers
Amino acids
Peptide bond
A bond used by amino acids to form proteins
Most important part of a protein?
Structure
The four basic levels of protein structure
- Primary
- secondary
-Tertiary - quaternary
Primary structure
Spatial relationship of adjacent amino acids
Secondary structure
Spatial relationship of neighboring amino acids
Tertiary
Spatial relationship of distantamino
Quaternary
Spatial relationship of amino acids in separate polypeptide chains,
Hydrolysis dehydration
Use’s water to breakdown polymers into monomers
Polymers
A substance or material consisting of very large molecules
Alpha
Helices
Beta
Pleated sheets
5 important types of R-group interactions
- hydrogen bonds
- hydrophobic interactions
- van her walls interactions
- covalent disulfide bonds
-Ionic bonds
Hydrogen bonds
Form between polar side chains and opposite partial
Hydrophobic interactions
Water forces hydrophobic side chains together
Van her walls interactions
Weak electrical interactions between hydrophobic side chains
Ionic bonds
Form between groups with full and opposing charges
Aspartate
One letter code: D
Abbreviation: asp
Property: ionic & acidic
Glutamate
One letter code: E
Abbreviation: glu
Property: ionic & acidic
Lysine
One letter code: k
Abbreviation: Lys
Property: ionic & basic
Arginine
One letter code: R
Abbreviation: arg
Property: ionic & basic
Histidine
One letter code: H
Abbreviation: His
Property: ionic & basic