Chapter 3

Question 1

What is cross-tolerance?

Answer 1

Tolerance to one drug will diminish the effect of another drug.

Question 2

What is acute tolerance?

Answer 2

Tolerance that develops to the effect of a drug during a single administration.

Question 3

What are the mechanisms of tolerance?

Answer 3

Metabolic tolerance(pharmacokinetic): increased metabolism due to enzyme induction. 
Physiological tolerance(pharmodynamic): adjustment in the physiology of the body to compensate for the effect of the drug.

Question 4

When does tolerance develop?

Answer 4

Tolerance only develops to the effect Ida drug that creates a functional disturbance; ie effects that activate homeostatic feedback.

Question 5

What are withdrawal symptoms?

Answer 5

Changes that occur when the use of a drug is stopped or dosage reduced.

Question 6

What is “dependence”?

Answer 6

(a) the state where discontinuing a drug will cause withdrawal (better definition)
(b) the state where a person compulsively takes a drug

Question 7

What is drug tolerance?

Answer 7

A decrease in the effect with repeated doses of a drug or the necessity of increasing the dose to maintain the same effect of adrift if it repeatedly administered. Tolerance develops to the effect of the drug, not to the drug itself.