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Behavioural Pharmacology and Teratology > Chapter 3 > Flashcards

Chapter 3 Flashcards

1
Q

Everything in the nervous system is described in relation to ____?

A

The Nuraxis

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2
Q

The front end is called _____ and the tail end is called ______

A

Anterior; Posterior

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3
Q

Toward the beak_____; toward the tail_____

A

Rostral; Caudal

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4
Q

Top of the head ______; towards the ground ______

A

Dorsal;Ventral

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5
Q

Superior = _____; Inferior =_____

A

Above; Below

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6
Q

Lateral means towards the ____; L Medial towards the ______.

A

Side/Edge;Middle/Inwards

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7
Q

Structures on the same side of the body are called

A

Ipsilateral

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8
Q

Structures on the opposite sides of the body are called

A

Contralateral

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9
Q

To cut the nervous system tranverserly means to cut it into _____?

A

Cross-sections

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10
Q

When you cut the nervous system Parallel to the ground it

gives you _______ sections

A

Horizontal

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11
Q

When you cut the nervous system Perpendicular to the ground and parallel to the nuraxis is gives _____ sections

A

Sagittal

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12
Q

The ______ divides the brain into two halves

A

Midsaggital sections

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13
Q

The entire nervous system (CNS & PNS) is covered by tough connective protective sheath called ______?

A

meninges.

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14
Q

Mengies have three layers these are
1.
2.
3.

A
  1. Dura Matter
  2. Arachnoid Membrane
  3. Pia Matter
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15
Q

The outer layer of the Mengies is called ____? and its characteristics are ?

A

Dura Matter, very thick, tough, lexable

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16
Q

The middle layer of the Mengies is called _____ ? and its characteristics are ?

A

Arachnoid Membrane, Soft and Spongy

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17
Q

The most inner layer of the mengies is called _____? and its characteristics are ?

A

Pia Matter, closely attached to the brain and spinal cord

the smaller surface blood vessels of the brain and spinal cord are contained in this layer

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18
Q

The CNS is covered in all three layers of mengies but the PNS is only covered in _____ & _____?

A

Dura Mater, Pia Mater

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19
Q

The Space between Between the pia mater and the arachnoid membrane is called the _____? this space is filled with ______?

A

Subarachnoid space; Cerebrospinal Fluid

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20
Q

The outermost layer of grey matter of the cerebral hemisphere is called the ____?

A

Cerebral Cortex

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21
Q

The brain contains several hollow interconnected chambers called ______ which are filled with ______

A

Ventricles; CSF

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22
Q

The largest chambers in the brain are the ________? which are connected to the _________?

A

Lateral Ventricles; Third Ventricle

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23
Q

The brain is divided into two symmetrical halves and the _______ walls line this division

A

Third Ventricle

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24
Q

choroid plexus is important because?

A

It manifactures the CSF

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25
Q

CSF has a half life of three hours; what does this mean?

A

This is the time it takes for half of the ventricular system to replace half of the CFS with fresh fluid.

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26
Q

What is the approx. amount of CSF?

A

125ml

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27
Q

The Process for CFS Removal

CFS i produced by the choroid plexus of the lateral vesicles and then flows into the __________ where more CFS is then produced which then flows through the _______ to the fourth ventricle where more CFS is produced. CFS then leaves the fourth ventricle through small opening that connect with the subarachnoid space surrounding the brain and flows through around the ______ where it is reabsorbed into the blood supply through arachnoid granulations.

A

Third Ventricle; Cerebral Aqueduct; CNS

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28
Q

The Process for CFS Removal

CFS i produced by the _______ of the lateral vesicles and then flows into the third ventricle where more CFS is then produced which then flows through the cerebral aqueduct to the________ where more CFS is produced. CFS then leaves the fourth ventricle through small opening that connect with the subarachnoid space surrounding the brain and flows through around the central nervous system where it is _______ into the blood supply through arachnoid granulations.

A

Choroid Plexus; Fourth Ventricle; Reabsorbed

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29
Q

hydrocephalus means?

A

Water Head - buildup and enlargement of vesicles

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30
Q

When does the development of the human nervous system begin?

A

Around the 18th day after conception

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31
Q

21 Days after conception ridges begin to touch each other and fuse together forming ________?

A

Neural Tube

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32
Q

What happens by day 28 after conception?

A

The neural tube closes

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33
Q

By day 28 after conception the neural tube is closed, and its rostral end (front) has developed three interconnected chambers, these are ventricles, and the tissue surrounding them becomes the three major parts of the brain;

A
  1. Forebrain
  2. Midbrain
  3. Hindbrain
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34
Q

_____ line the inside of the neural tube and give rise to the cells of the ______

A

Stem Cels; CNS

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35
Q

There cerebral cotex develops from the inside out and is made up of ___ layers

A

6

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36
Q

The stem cells that give rise to the cells in the brain are known as _______ cells.

A

Progenitor

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37
Q

The CNS origionates from the _____ during developmentq

A

Neural Tube

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38
Q

The outermost layer of grey matter of the cerebral hemisphere is called the ?

A

Cerebral Cortex

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39
Q

A layer of cells that line the inside of the neural tube; contains progenitor cells that divide and give rise to cells of the CNS

A

Ventricular Zone

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40
Q

A layer of progenitor cells located just inside the ventricular zone; thicker in mammals with large brains

A

Sub ventricular Zone

41
Q

The size of the VZ is increased because ?

A

New Progenitor cells are made and increase the size of the VZ.

Some continue to divide into more progenitor cells and establish the sub ventricular zone (SVZ) - this phase is referred to as the Symmetrical Division. - it is called this because each division of a progenitor cell produced two new progenitor cells increasing the size of the VZ & SVZ.

42
Q

When Progenitor cells increase what happens?

A

Some divide, into more progenitor cells and establish the SVZ - this is symmetrical division.

43
Q

What is symmetrical division?

A

When progenitor cells divide two new cells are produced

44
Q

How is the SVZ created?

A

By symmetrical division of the Progenitor cells

45
Q

What is Asymmetrical Division?

A

When progenitor cells form two different kinds of cells as they divide; another progenitor cell and a brain cell (radial glia)

46
Q

7 Weeks after conception the Progenitor cells receive a message to stop symmetrical division and begin ______?

A

Asymmetrical Division

47
Q

How long does the period of Asymmetrical divison last?

A

Around 3 months

48
Q

In Asymmetrical division radial glia are made. The cell bodies of the radial glia extend outwards from the ________ and attach to _______ located at the outer surface of what becomes the cerebral cortex.

A

Ventricular Zone; Pia Matter

49
Q

Neurogenesis occurs in the _____ and the _____

A

Hippocampus; Olfactory Bulb

50
Q

The end of cortical development is because of _______?

51
Q

Apoptosis is?

A

When progenitor cells receive a chemical signal that causes them to die

52
Q

When progenitor cells receive a chemical signal that causes them to die it is called

53
Q

At the time of Apoposis, _______ are transformed into Astorcytes

A

Radial Glia

54
Q

Neurogenesis is ?

A

Production of new neurons through the division of neural stem cells

55
Q

The ultimate size of the brain is determined by the size of _______

56
Q

The subventricular zone of ____________ is much thicker than that of smooth brains, it can be divided into two parts -
1 ____? 2_____?

A

Convulted Brains; the inner SVZ and the outer SVZ

57
Q

The surface area of the brain is increased because it is ________?

58
Q

Once neurons have migrated to their final location they _______________? grow dendrites which receive the terminal buttons from axons and of other neurons and grow axons of their own.

A

Forming connections with other nerons

59
Q

The growth of axons is guided by ______ and physical factors

60
Q

Once growth of an axon ends and their target is reached they form ___________
- each of these branches finds a vacant place on the membrane of the appropriate type of postsynaptic cell, grows a __________ and establishes a __________connection.

A

Branches; Terminal Button, Synaptic

61
Q

The hippocampus is primarily involved in ?

62
Q

The Olfactory Bulb is primarily involved in

A

The sense of smell

63
Q

The adult brain contains stem cells that can divide and produce _________?. Detection of newly produced cells is done by administering a small amount of a radioactive form of one of the nucleotide bases the cells use to produce DNS that is needed for neurogenesis.

64
Q

Neurogenesis can be supressed by

A

depression and/or stress

65
Q

Neurogenesis can be reinstated by __?

A

Drugs that reduce stress/depression

66
Q

During the first phase of brain development, _____________ of the progenitor cells of the ventricular and sub-ventricular zones, which lines the neural tubes, increases in size.

A

Symmetrical Division

67
Q

During the second phase of brain development, ___________ of these cells gives rise to neurons, which migrate up the fibers of radial glial cells to their final resting places. There, neurons develop dendrites and axons and establish synaptic connections with other neurons.

A

Asymetrical Division

68
Q

When a gene is duplicated, one of the copies can continue to perform vital functions, leaving the other copy for __________ through mutations.

A

Experimentation

69
Q

The outer part of the spinal cord consists of __________; axons conveying information up or down.

A

White Matter

70
Q

The central grey matter contains ?

A

Cell Bodies

71
Q

Two main functions of the spinal cord is to distribute motor fibres to the effector origins of the body (glands and muscles) and to _________________?

A

collect somatosensory information to be passed onto the brain.

72
Q

The spinal cord has a degree of ______ from the brain because of _______ controlling various circuits.

A

Autonomy; Reflexes

73
Q

The Spinal cord is protected by __________ - this is composed of 24 _____________

A

vertebral column; individual vertebrae

74
Q

The spinal cord only fills around two-thirds of the vertebral column; the rest of the space is filled by a mass __________ composing the cauda equina (a bundle of spinal roots located caudal to the end of the spinal cord).

A

Spinal Roots

75
Q

What is the Cauda Equina?

A

A bundle of spinal roots

76
Q

A Fissure is

A

A major groove in the surface of the brain

77
Q

A Sulcus is

A

A groove in the surface of the cerebral hemisphere, smaller than a fissure

78
Q

A convolution of the cortex of the cerebral hemispheres, separated by sulci or fissures is call ____?

79
Q

This is something used in surgery where local aesthetic is injected into the CSF contained within the sac of dura mater surrounding the cauda equina.
This blocks that conduction in the axons.

A

Caudal Block

80
Q

Layers of mengies wrap the spinal cord with small bundles of fibre emerging from each side of the spinal cord, these groups of bundles fuse together and becomes the thirty one paired sets of ________and___________.

A

Dorsal Roots; Ventral Roots

81
Q

Afferent Means

82
Q

Efferent means

83
Q

The spinal root that contains the incoming (afferent) sensory fibres is the

A

Dorsal Roots

84
Q

The spinal root that contains the outgoing (efferent) motor fibers

A

Ventral Roots

85
Q

The brain and spinal cord communicate with the rest of the body via cranial nerves and spinal nerves - these nerves are part of the _______?

86
Q

Development of the nervous system begins around the ____ day of conception

87
Q

There are ____ pairs of cranial nerves attached to the ventral surface of the brain

88
Q

The largest of the cranial nerves, conveying efferent fibers of the parasympathetic division of the autonomic nervous system to organs of the thoracic and abdominal cavities is called the ?

A

Vagus Nerve

89
Q

Somatosensory information (taste) is received via cranial nerves, from _______ neurons

A

Unipolar Neurons

90
Q

What is involved in the somatic nervous system which is part of the PNS?

A
  • Auditory,
  • Vestibular and
  • Visual information is received via the olfactory bulbs
91
Q

What is the role of the Autonomic Nervous System?

A

Regulation of smooth muscle

ie. skin, blood vesicles, eyes, and walls of the gut, gallbladder, urinary tract, cardiac muscle and glands.

92
Q

What are the two division of the Autonomic Nervous System?

A
  1. Sympathetic Divison

2. Parasympathetic Division

93
Q

What is the role of the sympathetic division in the Autonomic nervous system of the PNS

A

Controls activities that occur during excitement or exertion

- expenditure of energy

94
Q

Give an example of the excitement or exertion that occurs in the Sympathetic division of the Autonomic nervous system of the PNS

A

Increased Heart rate

95
Q

What is the role of the parasympathetic divison of the Autonomic nervous system of the PNS

A

Activities that increase the bodys supply of stored energy.

96
Q

What is an example of what the parasympathetic divison of the Autonomic nervous system of the PNS does?

A

controls activities that occur during relaxation, such as decreased heart rate and increased activity of the digestive system.

97
Q

What does the The adrenal medulla do?

A

secretes epinephrine and norepinephrine is controlled by axons of the sympathetic nervous system

98
Q

What controls the adrenal medulla located?

A

The Sympathetic Nervous System

Behavioural Pharmacology and Teratology (3 decks)

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