Chapter 29 - Analytical Toxicology

Question 1

If a human sample is made basic and extracted with an organic solvent and then the nonorganic phase is acidified and extracted again with organic solvent the final organic extract will contain mostly…

A. Basic drugs

B. Neutral drugs

C. Acidic drugs

D. Volatiles

Answer 1

C. Acidic drugs

Question 2

Venoms usually need to be measured by a combination of monoclonal antibodies and…

A. Gas chromatography

B. infrared spectroscopy

C. Liquid chromatography

D. Immunoassay

Answer 2

D. Immunoassay

Question 3

Analytical toxicology measurements are least valuable in…

A. Establishing bioavailability of a poorly absorbed drug

B. assessing pharmacodynamic drug interactions

C. Identifying contaminants in a drug mixture

D. Assessing pharmacokinetic drug interactions

Answer 3

B. assessing pharmacodynamic drug interactions

Question 4

In order for an analytic toxicology result to be entered into legal proceedings, there usually must be…

A. Chain of custody

B. 3 repeat analyses

C. Blood results, not tissue or urine

D. Analysis by a board-certified forensic toxicologist

Answer 4

A. Chain of custody

Question 5

The precision of an analytic toxicology result is related to…

A. Location value falls on standard curve

B. Accuracy of value on repeated measurements

C. Whether dilution was necessary

D. Accuracy of blood value compared to tissue

Answer 5

B. Accuracy of value on repeated measurements

Question 6

Identification of anhydroecgonine methyl ester along with cocaine metabolites in the urine is an indication that…

A. Cocaine was adulterated with PCP

B. cocaine was administered orally

C. Cocaine was smoked

D. Cocaine was ingested with ethyl alcohol

Answer 6

C. Cocaine was smoked

Question 7

The least useful specimen for quantitative toxicologic analysis is…

A. Blood

B. liver

C. Urine

D. Vitreous humor

Answer 7

C. Urine

Question 8

By identifying the presence of certain impurities in biological samples obtained after consumption of an illicit substance one can…

A. More accurately predict the time of ingestion

B. More accurately predict the mode of ingestion

C. More accurately predict drug-drug interactions

D. Possibly identify the source of the illicit material

Answer 8

D. Possibly identify the source of the illicit material

Question 9

The classic Mickey Finn of the nineteenth century was a mixture of ethyl alcohol and..

A. Isopropyl alcohol

B. Chloral hydrate

C. Butalbital

D. Meprobamate

Answer 9

B. Chloral hydrate

Question 10

A child who is intentionally poisoned by parents to repeatedly appear ill is part of a syndrome known as…

A. Munchausen syndrome

B. Munchausen by proxy syndrome

C. Borderline personality syndrome

D. DSM IV syndrome

Answer 10

B. Munchausen by proxy syndrome

Question 11

Analysis of how much hair will provide an approx monthly pattern of arsenic exposure?

A. 1 mm

B. 5 mm

C. 12 mm

D. 25 mm

Answer 11

C. 12 mm

Question 12

All of the following tests can help detect adulteration of a urine specimen for forensic testing except…

A. pH

B. creatine

C. Specific gravitiy

D. Pressure of WBCs

Answer 12

D. Pressure of WBCs

Question 13

In order to distinguish heroin use from poppy seed ingestion one should look for the presence of…

A. 6-monacetylmorphine

B. Morphine glucuronide

C. Codine

D. Hydromorphone

Answer 13

A. 6-monacetylmorphine

Question 14

All of the following are commonly used to adulterate urine for drug testing purposes except…

A. Bleach

B. Baking soda

C. Glutaraldehyde

D. Methylene blue

Answer 14

D. Methylene blue

Question 15

Use of Vicks inhaler may result in a false positive urinary drug screen for…

A. Opiates

B. PCP

C. D-methamphetamine

D. L-methamphetamine

Answer 15

C. D-methamphetamine

Question 16

A rapid quantitative determination of serum conc of all of the following drugs is required in an overdose setting except

A. Acetominophen

B. ethanol

C. Ibuprofen

D. Ethylene glycol

Answer 16

C. Ibuprofen

Question 17

A commonly used term to denote the serum level of a drug that should be immediately reported to the treating physician is…

A. Panic level

B. Lethal level

C. Toxic level

D. Subtherapeutic level

Answer 17

A. Panic level

Question 18

Traditionally, therapeutic frug monitoring has been performed for all of the following drug classes except…

A. Antimicrobials

B. Antihypertensives

C. Anticonvulsants

D. Antiarrhythmins

Answer 18

B. Antihypertensives

Question 19

In usual cases, toxicologic analysis of dead bodies has involved the use of all of the following except…

A. Maggots

B. Hair

C. Clothing

D. Bones

Answer 19

C. Clothing

Question 20

Interference with toxicologic analysis will least likely result from contaminants present in…

A. Specimen containers

B. Air

C. Lids

D. Stoppers

Answer 20

B. Air

Question 21

When analyzing a specimen where extraction efficiency is highly variable, one can use the method of…

A. Standard additions

B. Least squares

C. Standard curves

D. Internal standards

Answer 21

A. Standard additions

Question 22

Which of the following would be thought to have the highest degree of post-mortem redistribution?

A. Mecuric ion

B. Ethanol

C. Paraquat

D. Imipramine

Answer 22

D. Imipramine

Question 23

Which of the following is true of a urine drug screen?

A. Chain of custody is not required for forensic evidence

B. over 50 drug classes can be rapidly screened

C. There is a poor correlation between levels and clinical effects

D. They are commonly run by HPLC

Answer 23

C. There is a poor correlation between levels and clinical effects

Question 24

The largest group of substances that must be considered by analytical toxicologists are…

A. Nonvolatile organic substances

B. metals

C. Gases

D. Volatile substances

Answer 24

A. Nonvolatile organic substances