Chapter 29

Question 1

What are the components of hemoglobin?

Answer 1

2 alpha subunits plus 2 beta subunits. EACH subunit has an Fe2+ - Heme group plus a globin group.

Question 2

Why is the hemoglobin (Hb) - O2 curve sigmoidal?

Answer 2

Because of cooperative binding among the four subunits of hemoglobin

Question 3

What are 3 characteristics of metabolically active tissues?

Answer 3

1. Increase in [H+]
2. Increase in pCO2
3. Increase in temperature

Question 4

What does 2,3 bisphosphoglycerate do?

Answer 4

Reduces the affinity of adult hemoglobin for oxygen, but does not affect the affinity of fetal hemoglobin.

Question 5

How does the blood carry CO2, a gas?

Answer 5

In the form of HCO3-

Question 6

What are the 3 variables responsible for CO2 transport in the blood?

Answer 6

1. Carbonic Anhydrase (CA)
2. The Cl/HCO3 exchanger
3. Hemoglobin

Question 7

High pO2 in the lungs causes what to happen to CO2?

Answer 7

High pO2 causes the blood to dump (get rid of) CO2.