Chapter 25 (Urea Cycle)

Question 1

High concentration of ammonia will shift the Glutamine synthetase equilibrium in the favor of (glutamine/glutamate) which depletes the ATP levels in the ___

Answer 1

glutamine

brain

Question 2

Which two AA are in the highest concentration in the blood

Answer 2

Alanine and Glutamine

Question 3

Long term muscle exertion uses the ___ cycle

Answer 3

alanine

associate ala with muscle

Question 4

The urea cycle is mainly done in the ___ and starts off in the ___

Answer 4

liver

mitochondrial matrix

Question 5

Carbonyl Phosphate Synthetase I (CPSI)

Answer 5

First committed step in the urea cycle

one of the professors favorite enzymes!

Question 6

What is a + allosteric effector of CPSI

Answer 6

N-acetyl glutamate

Question 7

Deficiency of Beta-Oxidation can lead to 3 problems:

Answer 7

hypoglycemia
hypoketotic
hyperamonemia
(all means no energy for fasting conditions)

Question 8

What happens to AA during fasting conditions

Answer 8

it is transferred to the liver in order to maintain blood glucose level, this causes and increase in [ammonia]

Question 9

Which enzyme of the Urea Cycle takes the pathway from inside the mitochondrial matrix to the cytosol

Answer 9

Ornithine transcarbamoylase

Question 10

Which enzyme of the Urea Cycle links the cycle with the TCA cycle

Answer 10

Arginosuccinate lyase

because it creates fumarate

Question 11

The Urea Cycle is the only way to synthesize which AA

Answer 11

Arginine

Question 12

For the final be able to draw the urea cycle and the mechanism behind PLP

Answer 12

do it