Chapter 25- Mycoplasma and Cell-Wall Defective Bacteria Flashcards
Causes postpartum fever and uterine tube infections
Mycoplasma hominis
Causes nongonococcal urethritis in men, lung disease in infants with low birth weight
Ureaplasma urealyticum
Closely related to M.pneumoniae associated with urethral and urogenital infections.
Mycoplasma genitalium
The smallest genome of known mycoplasmas
M. genitalium
Characteristics of mycoplasma
- Small 125-250 nm
- Pleomorphic
- Resistant to penicillin
- Reproduce in cell-free media
- Inhibited by specific antibody
- Has an affinity to mammalian cell membranes
Culture for mycoplasma
Media with serum (glucose,urea, yeast extract)
Parasitic mycoplasma grow on cell-free media that contain
lipoprotein and sterol
CF antigens of mycoplasmas are
Glycolipids
Antigens of mycoplasma for ELISA are
Proteins
Associated with P1 adhesin
M. pneumoniae
Associated with MgPa adhesin
M.genitalium
Mycoplasma attached to the surface of ciliated and non-ciliated cells through
Mucosal cell sialoglycoconjugates
Sulfated glycolipids
Specimes for the diagnostic lab test for mycoplasma
Throat swabs
Sputum
Inflammatory exudates
Respiratory, Urethral or genital secretions
IP of M.hominis and U.urealyticum
2-4 days
IP of M.pneumoniae
4 weeks
Test used to cultivate M.pneumoniae
NAATs
Treatment against Mycoplasma
Tetracycline
Erythromycin
Mycoplasma are resistant to
Penicillin
Cephalosporins
Vancomycin
M. genitalium in men is treated with
single dose of Azithromycin
Titer for diagnosis for M.pneumoniae
1:64 or more
