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Microbiology > Chapter 20- Neisseriae > Flashcards

Chapter 20- Neisseriae Flashcards

1
Q

human pathogen that is associated with or inside polymorphonuclear cells

A

Neisseria meningitidis (meningococci)

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2
Q

Gram-negative, nonmotile diplococcus, 0.8 um kidney-bean shaped

A

Typical Neisseria

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3
Q

In what hour does gonococci and meningicocci form convex, glistening, elevated mucoid 1-5 mm in diameter

A

48 hours

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4
Q

Describe colonies of a typical Neisseria

A

Transparent or opaque, nonpigmented and non-hemolytic

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5
Q

Nesseria species that produces yellow pigment

A

N.flavescens
N. subflava
N. cineria
N. lactamica

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6
Q

Nesseria sp that produces opaque, brittle, wrinkled colonies

A

N.sicca

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7
Q

produces nonpigmented or pinkish gray opaque colonies

A

Moraxella catarrhalis

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8
Q

Nesseria species that oxidizes glucose

A 
N. gonorrhea 
N. meningitidis
N. lactamica
N. sicca
N. subflava
N. mucosa
N. polysaccharea
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9
Q

Nesseria species that oxidizes maltose

A 
N. meningitidis 
N. lactamica
N. sicca
N. subflava
N. mucosa
N. polysaccharea
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10
Q

Nesseria species that oxidizes lactose

A

N. lactamica

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11
Q

Nesseria species that oxidizes sucrose

A

N. sicca
N. subflava
N. mucosa

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12
Q

Nesseria species that has DNAse

A

Moraxella catarrhalis

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13
Q

Media where meningococci and gonococci grows best

A 
On organic substances 
Heated blood
Hemin
Animal proteins
5% CO2
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14
Q

Growth of meningococci and gonococci is inhibited by

A

Fatty acids and salts

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15
Q

meningococci and gonococci are rapidly killed by

A

drying
sunlight
moist heat
disinfectants

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16
Q

Gonococci require these products in order to grow

A

Arginine
Hypoxanthine
Uracil

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17
Q

Colonies of gonococci in selective subculture

A

Small colonies with piliated bacteria

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18
Q

Colonies of gonococci in nonselective subculture

A

Larger colonies with non-piliated gonococci

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19
Q

Antigenic structure of N.gonorrhea

A
  1. Pili (Fimbrae)
  2. Por
  3. Opa proteins
  4. Rmp (Protein III)
  5. Lipooligosaccharide
  6. Lip (H8)
  7. Fbp (ferric-binding protein)
  8. IgA1 protease
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20
Q

Antigenic structure of N.gonorrhea that enhance attachment to host cells and resistance to phagocytosis

A

Pili (fimbriae)

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21
Q

Antigenic structure of N.gonorrhea that prevents phagosome-lysosome fusion

A

Por proteins

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22
Q

Antigenic structure of N.gonorrhea that function in adhesion within colonies and their attachment to host cell receptors

A

Opa proteins

23
Q

Antigenic structure of N.gonorrhea that is associated with Por in the formation of pores in the cell surface

A

Rmp (Protein III)

24
Q

Antigenic structure of N.gonorrhea that helps them evade immune recognition of the host cell

A

Lipooligosaccharide

25
Q

Antigenic structure of N.gonorrhea that is a surface-exposed protein that is heat modifiable like Opa.

A

Lip (H8)

26
Q

Antigenic structure of N.gonorrhea that is similar in MW to Por that is expressed when the iron supply is limited

A

Ferric-binding protein (Fbp)

27
Q

Antigenic structure of N.gonorrhea that splits and inactivates IgA1

A

IgA1 protease

28
Q

Por proteins selectively bind to what complement

A

C3b and C4b

29
Q

Opaque gonococci colonies is associated with?

A

Men with SYMPTOMATIC urethritis

Uterine cervical cultures at midcycle

30
Q

Transparent gonococci colonies is associated with

A

ASYMPTOMATIC urethral infection in men
Menstruating women
Patients with invasive form of gonorrhea

31
Q

Treatment prevention for gonococcal ophthalmia neonatarum (SET)

A

silver nitrate
erythromycin
tetracycline

32
Q

Specimes for diagnostic lab tests for N.gonorrheae

A

Pus
Secretions
Synovial fluid
Blood culture

33
Q

Tests for gonococcal smears in women

A

NAATs or cultures

34
Q

Media best for gonococci

A

Modified Thayer-Martin medium (MTM) 5% CO2 at 37 C

35
Q

To avoid overgrowth of gonococci, selective medium must contain (T-VAC)

A

Trimethoprim (3 ug/mL)
Vancomycin (3 ug/mL)
Amphotericin B (1 ug/mL)
Colistin (7.5 ug/mL)

36
Q

_____ hours after culture, gonococci that can identified by gram-stained smear

A

48 hours

37
Q

Gonococci can be identified through

A

Oxidase positive
Coagglutination
Immunofloresence

38
Q

Test for direct detection of N.gonorrhea

A

NAATs

39
Q

Antibodies present against gonococcal pili, outer membrane proteins and LPS

A

IgA
IgG
IgM

40
Q

Antibodies against gonococcal pili, and outer membrane proteins are detected by

A

Immunoblotting
Radioimmunoassay
ELISA

41
Q

Treatment for gonococcal infections

A

IM ceftriaxone 250 mg

Oral cefixime 400 mg

42
Q

Treatment for gonococcal infections with concomitant chlamydial infections

A

1 g Azithromycin or

100 mg of Doxycycline oral for 7 days

43
Q

Treatment for gonococcal ophthalmia neonatarum

A

0.5% erythromycin ophthalmic ointment

1 % tetracycline ointment for conjunctiva

44
Q

Most important serogroups of N.meningitidis that are associated with human disease

A

A, B, C, X, Y and W-135

45
Q

Meningococcal antigens are found in

A

Blood and CSF

46
Q

The outer membrane of N.meningitidis contains these things that plays a role in their virulence

A

Proteins and LPS

47
Q

Responsible for toxic effects of meningococcal disease

A

Lipid A disaccharide of meningococcal LPS

48
Q

Portal on entry of N.meningitidis

A

Nasopharynx

49
Q

Meningococci are readily phagocytosed in the presence of

A

Specific opsonin

50
Q

Specimens used for diagnostic lab tests for meningococci

A

NP swab culture

Puncture material from petechiae

51
Q

Culture media for N. meningitidis

A

CSF on chocolate agar at 37 C 5% CO2

52
Q

Drug of choice for N. meningitidis

A

Pen G

53
Q

Drug for N. meningitidis that is allergic to Pen G

A

Chloramphenicol

3rd Gen Cephalosporins (Cefotaxime or ceftriaxone

54
Q

M.catarrhalis produces this enzyme that forms the basis for rapid fluorometric tests

A

Butyrate esterase

Microbiology (7 decks)

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