Chapter 24 (Eicosanoids)

Question 1

Arachidonic Acid is a precursor to ____ which are local ___

Answer 1

eicosanoids

hormones

Question 2

___ and ___ triggers arachidonic acid release and ___ synthesis

Answer 2

Tissue damage and inflammation

eicosanoid

Question 3

Why are eicosanoids considered local hormones

Answer 3

Because they have a very short half-life

Act near the area of synthesis (in the endoplasmic reticulum)

Question 4

The first step in eicosaanoid biosynthesis is the epoxidation and cyclization by ___

Answer 4

COX

Question 5

Leukotriene

Answer 5

does not need COX or eicsonoid precursor

Question 6

Nonsteroidal noninflammitory drugs target:

Answer 6

COX I

COX II

Question 7

Results of inhibiting:
COX I
COX II

Answer 7

I = platelets do not aggregate 
II = increase the chance of heart attack

Question 8

COX I

Answer 8

always expressed, important, in all tissues

works with blood and mucin secretion

Question 9

COX II

Answer 9

low expression, not in all tissues, inducible

deals with pain, inflammation and fevers

Question 10

Thromboxan A2

Answer 10

produced by platelets to stimulate platelet aggregation

Question 11

Tylenol and Ibuprofen

Answer 11

competitive inhibitors (means they are reversible)
Tylenol does not deal with inflammation

Question 12

Asprin

Answer 12

Irreversible inhibitor

Question 13

COX III

Answer 13

Rumored to exist in nerve tissue, discovered by Tylenol company

Question 14

COX (I/II) inhibitors put us at a greater risk of strokes and heart problems

Answer 14

II (Celebrex and Vioxx)