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Path Midterm > Chapter 23 (2) > Flashcards

Chapter 23 (2) Flashcards

1
Q

BENIGN tumor of keratinocytes with FLAT, ROUND “COIN LIKE” PLAQUES for lesions, MC in MIDDLE AGED or ELDERLY and may be very numerous

A

seborrheic keratosis

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2
Q

With numerous SEBORRHEIC KERATOSIS there is possible paraneoplastic syndrome, which is known by the _________ sign, an explosive onset

A

leser-trelat

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3
Q

The velvety, granular, or scaly appearance of SEBORRHEIC KERATOSIS mimics which aggressive condition

A

malignant melanoma

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4
Q

Rare BENIGN skin condition with FLESH COLORED PAPULE that are SLOW GROWING, MC in older adults in head & neck regions

A

sebaceous adenoma

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5
Q
  • Dysplasia precedes EPIDERMAL CA in _______, which is from UV light and presents with tan, brown, red “SANDPAPER LIKE” lesions
A

actinic keratosis

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6
Q

ACTINIC KERATOSIS is very common, found in ________ % of US adults

A

11-26%

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7
Q
  • AKA LIVER SPOTS, ________ is from HYPERPLASIA of MELANOCYTES from PROLONGED UV EXPOSURE from aging
  • Cosmetic concern, but MAY DISGUISE CA
A

solar lentigo

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8
Q

Sun related skin changes from cumulative UVA & UVB exposure either natural or synthetic - AKA PHOTO-AGING

A

dermatoheliosis

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9
Q

__________ is from INCREASED SUN EXPOSURE over a lifetime, in OLDER ADULTS, potentially from TAR/OIL or ARSENIC exposure

A

squamous cell carcinoma

2nd MC skin CA

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10
Q

Squamous cell carcinoma arises from ________, and has WELL DEFINED LESIONS, SCALING DARK BORWN/RED and is not very aggressive

A

actinic keratoses

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11
Q

If SCC results from burn scars, ulcers, or are in non sun exposed regions, the CA is less

A

predictable

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12
Q

MC form of skin CA WORLDWIDE, arises from high overall sun/UV exposure and mutated TSGs such as the PTCH gene which has an impact on the HEDGEHOG PATHWAY

A

basal cell carcinoma

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13
Q

In BCC, the cells RESEMBLE NORMAL BASAL cells but the lesions resemble _________, and if advanced can cause ulceration following severe neglect

(BASAL CELL CARCINOMA)

A

pearly papules

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14
Q

Within 5 years of BCC removal, 40% of individuals develop:

A

2nd BCC

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15
Q

Transformed DENDRITIC MELANOCYTES that are tan-brown, uniform pigment, round, solid, well-defined margins
- “BEAUTY MARK”

A

common nevus

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16
Q

A _______ nevus is a lesion that is >5mm, irreg borders, flat macules or slightly raised plaques with variable pigmentation

A

dysplastic

17
Q

________ dysplastic nevus has a LOW risk for melanoma, while _________ type has a 100% lifetime incidence of melanoma (HIGH RISK), and is considered premalignant with >10 lesions

A

sporadic

familial

18
Q
  • 3rd MC skin CA that is small and aggressive, can be lethal and is MC asymptomatic with some pruritis, but is MC dx in early stages
  • INTENSE sunlight exposure (bad burn), DYSPLASTIC NEVI are risks
A

melanoma

19
Q

Melanoma grows first _______ and then has _______ growth, which is a measure of mets risk

A

horizontal

vertical

20
Q

When advanced, melanoma can mets to lymph &/or blood, MC to these 3 areas

A

liver
lungs
brain

21
Q

INCREASED SIZE or CHANGE in COLOR, new lesions in adulthood, or highly dark pigmentation indicates increased _________ in melanoma

A

agressiveness

22
Q

ABCD of melanoma

A

asymmetry
border
color (Most IMPORTANT)
diameter (size-Most IMPORTANT)

23
Q

First to third MC skin cancers

A

BCC
SCC
malignant melanoma

24
Q

_______ is known as the GREAT IMITATOR due to is system wide affects, but also presents with a MALAR RASH

A

SLE

25
Q

_______ is a lymphatic tumor from HSV8 and is seen in AIDs patients as PURPLE lesions of the skin

A

kaposi sarcoma

26
Q

Skin tags, AKA ______ are fibroepi polyps of SQUAMOUS EPITHELIA with a FIBROVASCULAR CORE found in the CREASES of the body, MC of COSMETIC significance

A

acronchordon

27
Q

________ neurofibromatosis is MC and presents with neurofibromas and CAFE AU LAIT spots while ______ neurofibromatosis has bilateral VESTIBULAR SCHWANNOMAS

A

type I

type II

Path Midterm (4 decks)

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