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Path Midterm > Chapter 23 (1) > Flashcards

Chapter 23 (1) Flashcards

1
Q

_______ is a loss of keratinocyte adhesion

_______ is intracellular epidermal edema

A

acanthylysis

spongiosis

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2
Q

URTICARIA (hives) is a type I hypersensitivity & is either IgE-______ from pollen, food, venom, or IgE-______, from ADR’s like opiates, antibiotics etc

A

dependent

independent

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3
Q

Urticaria has wheals that MC fade w/i 24h, and is MC dx in patients ______ years old

A

20-40

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4
Q
  • Subcategory of URTICARIA that causes massive dermal swelling due to an inherited C1 ESTERASE INHIBITORY DEFICIENCY from an increased complement system activation
  • MC affects pharynx
A

hereditary angioedema

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5
Q

Broad category of cond that all share symptoms of: red, papulovesicular, oozing/crusted lesions

A

acute eczematous dermatitis (eczema)

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6
Q

ECZEMA can be hypersensitivity caused by either type _____ (delayed) or type _____ (allergy) and presents with itchy plaques, EDEMA, but with chronic exposure to the antigen will become _____

A

IV
I
hyperkeratotic (scaly)

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7
Q

MC subtype of ECZEMA, common in infants, TYPE IV hypersensitivity, LIMITED TO CONTACT SITE and is a lifelong pathology

A

allergic contact dermatitis

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8
Q

Subcategory of ECZEMA w/ strong genetic link (80% IDENTICAL TWINS) with a childhood onset of CHRONIC, RELAPSING, PRURITIC lesions that improve with age

A

atopic dermatitis

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9
Q

THREE symptoms that are seen in the ATOPIC TRIAD, associated with several HYPERSENSITIVITIES

A

dermatitis
asthma
allergic rhinitis

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10
Q

Skin disorders whose name refers to a wide variety of appearances, is a TYPE IV HYPERSENSITIVITY, and is either INFECTIOUS (HSV, fungi) or due from ADRs like ASPIRIN

A

erythema multiforme

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11
Q

Characteristic RED MACULE with an eroded or pale vesicular center, seen in erythema multiforme

A

targetoid

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12
Q

Lesions seen in ERYTHEMA MULTIFORME have ________ & ________ crusts, and if from ADRs can be found ANYWHERE.
- Secondary infxn are common and put pt at risk for sepsis

A

erosive

hemorrhagic

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13
Q

ERYTHEMA MULTIFORME is termed _______ when there are milder symptoms POST-INFECTION (MC hsv)

Termed ______ when it is from ADRs, as it causes severe epidermal damage

A

minor

major

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14
Q

LESS severe but life threatening ERYTHEMA MULTIFORME MAJOR, MC IDIOPATHIC but also from ADRs

A

stevens johnson syndrome

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15
Q

MORE severe and life threatening ERYTHEMA MULTIFORME MAJOR that affects >30% of the body and is less common

A

toxic epidermal necrolysis

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16
Q

Group of persistent conditions lasting from months to years with SCALE formation, ROUGH texture

A

chronic inflammatory dermatoses

17
Q

______ is very COMMON, is in 1-2% of the US population, is pruritic, and is usually from unknown antigens

A

psoriasis

18
Q

_______ is described as having WELL-DEMARCATED, PINK TO SALMON COLORED PLAQUE COVERED BY LOOSELY ADHERENT SILVER-WHITE SCALE

A

psoriasis

19
Q

PSORIASIS has _____ cells CD4+ & CD8+ produce GFs that increase kertinocyte growth

A

T cells

20
Q

UNREGULATED INFLAMMATION from local trauma in PSORIASIS in a linear pattern is called ____________, while _________ sign refers to multiple bleeding points when scale is scraped off

A

koebner phenomenon

auspitz

21
Q

6 p’s of LICHEN PLANUS

A 
pruritic
purple
polygonal
planar
papules
plaques
22
Q

LICHEN PLANUS shows T cells in the ______________ and while uncommon, is MC in:

A

dermoepidermal junction

middle aged adults

23
Q
  • Lesions of LICHEN PLANUS are SYMMETRICAL, itchy, and if white dots/lines are called ________
  • Symptoms resolve in 1-2 years SPONTANEOUSLY
A

wickham’s striae

24
Q

Idiopathic (but strongly rel to repetitive trauma), ROUGHENED SKIN with DERMAL SCARRING that may accompany ECZEMA or PSORIASIS is _________

A

lichen simplex chronicus

25
Q

Pre-malignant condition that is a DDx for LICHEN SIMPLEX CHRONICUS

A

actinic keratosis

26
Q

Common bact infx in children/athletes caused by STAPH AUREUS or STREP PYOGENES that presents lesions with HONEY COLORED CRUSTS

A

impetigo

27
Q

_______ infections (MYCOSIS), dermatophytosis (RINGWORM) can range from superficial to deep or systemic, which have posses GRANULOMA FORMATION

A

fungal

28
Q

Invasive ASPERGILLOSIS is ANGIOINVASIVE and can be aggressive, and is caused by

A

aspergillus fumigatus

29
Q

Tinea ________ is found on the NAILS
Tinea _______ is a FOLLICULITIS of the BEARD
Tinea ________ is found on NON-HAIRY SKIN TISSUE

A

unguium
barbae
corporis

30
Q

_______ are MC affected by VERRUCAE, which are from promoted epi growth, secondary to HPV infxn, MC HPV ________ & ________

A

pediatrics
6
11

31
Q

VERRUCA ________ is the MC type of WART, is gray white or tan on dorsal hand & PERIUNGUAL regions and is PEBBLE LIKE
VERRUCA _______ is FLAT & SMOOTH and is on FACE or dorsal hand

A

vulgaris

planus

32
Q

BULLOUS disorder may be secondary to other conditions but primary disorder have characteristic separation at specific ________

A

skin layers

33
Q

Rare, autoimmune bullous d/o seen in MC middle age/elderly resulting from a TYPE II HYPERSENSITIVITY & IgG autoantibodies that immunofluoresce with a FISHNET PATTERN

A

pemphigus

34
Q

Pemphigus _______ is MC and SUPRABASAL, in the MUCOUS MEMBRANES and skin while pemphigus ________ is SUBCORNEAL and RARE, LESS aggressive, and limited to skin

A

vulgaris

foliaceus

35
Q

__________ is an autoimmune TYPE II HYPERSENSITIVITY of SUBEPIDERMAL blisters, “tense bullae”, MC in ___________

A

bullous pemphigoid

older adults

36
Q

BULLOUS PEMPHIGOID shows linear IgG & complement, lymphocytes & neutrophils in the epidermal __________

A

basement membrane

37
Q

________ is a rare autoimmune condition, 80% of cases have CELIAC DISEASE, shows with pruritis, vesicles, urticaria on DORSAL ELBOW

A

dermatitis herpetiformis

38
Q

A skin biopsy showing IgA ANTIBODIES in the DERMAL PAPILLAE is seen for a dx of:

A

dermatitis herpetiformis

Path Midterm (4 decks)

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