Chapter 21: Carboxylic Derivatives Flashcards
1
Q
A
- carboxylic acid
2
Q
A
- acid chloride
3
Q
A
- anyhdride
4
Q
A
- ester
5
Q
A
- amide
6
Q
A
- Nitrile
7
Q
Reactivity of COOH derivatives differs from that of ketones and aldehydes because ____
A
- built in leaving group allows carbonyl to reform
8
Q
Rate the reactivities of COOH derivatives
A
9
Q
How to make acid chlorides
A
10
Q
A
11
Q
A
12
Q
A
13
Q
A
14
Q
A
15
Q
A
16
Q
Making anhydrides:
A
17
Q
A
18
Q
A
19
Q
A
20
Q
A
21
Q
A
22
Q
A
23
Q
A
24
Q
Two-step ester synthesis:
A
25
Q
Fischer Esterification (one-step ester synthesis)
A
26
Q
Hydrolyzing Esters
A
27
Q
If a molecule contains both a ___ and a ___ it can undergo intramolecular fishcer esterification.
A
- an OH and a COOH
28
Q
Making Amides:
A
29
Q
Hydrolysis of amides:
A
30
Q
Nitriles are still considered COOH derivatives because ___
A
- same oxidation state as other COOH derivatives
- meaning its carbon is also attached in three ways to a heteroatom
31
Q
Making Nitriles:
A
- Sn2- so only primary or secondary alkyl halides
32
Q
Hydration of Nitriles:
A
- In acid cataliyzed mechanism- all intermediates must be + or nuetral
- In base catalyzed mechanism- all intermediated must be - or nuetral
