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PET Study Guide Ed 3 > Chapter 2 > Flashcards

Chapter 2 Flashcards

1
Q

Clinical app: oncology- prostate
cardiac-oxidative metabolism (quantitative perfusion)

Uptake mech: fatty acid that tracks Krebs cycle

What’s this radiopharmaceutical?

A

C-11 Sodium acetate

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2
Q

Produced by CO-11^2 with grignard reagent, methyl magnesium bromide in diethyl ether

What radiopharmaceutical is produced?

A

C-11 Sodium acetate

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3
Q

Oncology- 6hr fast, inject, dynamic or delay 5mins, image

Cardiac- usually in conjunction with O-15 water perfusion study

What radiopharmaceutical matches these procedures?

A

C-11 Sodium acetate

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4
Q

Clinical app: oncology- malignancy

Uptake mech: fatty acid metabolism (cell membrane)

What 2 radiopharmaceuticals does this pertain too?

A

C-11 Choline and F-18 Choline

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5
Q

Produced by CO-11^2 reacting with dimethylethanolamine

What radiopharmaceutical is produced?

A

C-11 Choline

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6
Q

Oncology- fast, inject, delay, 5min, image

What 3 radiopharmaceuticals matches this procedure?

A

C-11 Choline, F-18 Choline, and C-11 Palmitate

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7
Q

F-18 fluoromethyltriflate and subsequently reacting with dimethylethanolamine and column purification

What radiopharmaceutical is produced?

A

F-18 Choline

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8
Q

Clinical app: oncology-malignancy
cardiac- viability
neurology- glucose metabolism

Uptake mech: glucose metabolism

What’s this radiopharmaceutical?

A

F-18 FDG

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9
Q

F-18 nucleophilic synthesis with mannose triflate precursor (Hamacher, 1986)

What radiopharmaceutical is produced?

A

F-18 FDG

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10
Q

Oncology- fast, inject, rest, 60-120min image
Cardiac- fast, euglycemic clamp, image
Neurology- fast, inject, delay 30-60min, image

What radiopharmaceutical matches these procedures?

A

F-18 FDG

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11
Q

Clinical app: bone imaging

Uptake mech: PO^-4 ioc exchange with hydroxyapatite crystals

What’s this radiopharmaceutical?

A

F-18 Sodium Fluoride

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12
Q

Capture F-18 on carbonate anion column, elute with potassium carbonate

What radiopharmaceutical is produced?

A

F-18 Sodium Fluoride

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13
Q

Inject, delay 1-2hr, image

What radiopharmaceutical matches this procedure?

A

F-18 Sodium Fluoride

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14
Q

Clinical app: oncology- prostate

Uptake mech: amino acid transport

What’s this radiopharmaceutical?

A

F-18 Fluciclovine Axumin

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15
Q

Nucleophilic substitution

What 4 radiopharmaceuticals are produced?

A

F-18 Fluciclovine Axumin
F-18 Fluoroestradiol (FES) Cerianne
F-18 Piflifolastat Pylarify
F-18 Tauvid

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16
Q

Perform CT, inject and begin imaging at 4mins pelvis through skull

What radiopharmaceutical matches this procedure?

A

F-18 Fluciclovine Axumin

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17
Q

Clinical app: oncology- breast cancer recurrency

Uptake mech: estrogen receptor uptake

What’s this radiopharmaceutical?

A

F-18 Fluoroestradiol (FES) Cerianne

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18
Q

Slow injection (1-2min), delay 80 min, image

What radiopharmaceutical matches this procedure?

A

F-18 Fluoroestradiol (FES) Cerianne

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19
Q

Clinical app: oncology- prostate

Uptake mech: PSMA binding

What 2 radiopharmaceuticals is this?

A

F-18 Piflifolastat Pylarify and Ga-68 PSMA

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20
Q

Inject, 60min uptake, image pelvis through skull

What radiopharmaceutical matches this procedure?

A

F-18 Piflifolastat Pylarify

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21
Q

Chelation

What radiopharmaceutical is produced?

A

Ga-68 PSMA

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22
Q

Inject, delay 50-100mins, image pelvis through skull

What radiopharmaceutical matches this procedure?

A

Ga-68 PSMA

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23
Q

Clinical app: oncology- cellular proliferation

Uptake mech: affinity to thymidine kinase 1 (TK1)

What’s this radiopharmaceutical?

24
Q

Nucleophilic substitution similar to FDG, but must extract FLT by HPLC

What radiopharmaceutical is produced?

25
Q

Inject, dynamic acquisition or delay 1hr, image

What radiopharmaceutical matches this procedure?

26
Q

Clinical app: oncology- hypoxia
cardiac- hypoxia

Uptake mech: binds to intracellular macromolecules if oxygen deficit

What’s this radiopharmaceutical?

A

F-18 FMISO

27
Q

Nucleophilic substitution similar to FDG, but must extract FMISO by HPLC

What radiopharmaceutical is produced?

A

F-18 FMISO

28
Q

Inject, dynamic acquisition or early imaging 10min and delayed imaging 60min

What radiopharmaceutical matches this procedure?

A

F-18 FMISO

29
Q

Clinical app: neurology- blood flow, blood volume, oxygen metabolism

Uptake mech: blood flow

What’s this radiopharmaceutical?

30
Q

N-14 (d,n) O-15

What radiopharmaceutical is produced?

31
Q

Regional cerebral blood flow, dynamic acquisition

What radiopharmaceutical matches this procedure?

32
Q

Clinical app: oncology- blood flow
cardiac- blood flow
neurology- blood flow

Uptake mech: blood flow

What’s this radiopharmaceutical?

A

O-15 water

33
Q

N-14 (d,n) O-15; O and H heated on palladium or platinum

What radiopharmaceutical is produced?

A

O-15 water

34
Q

Inject, dynamic acquistion

What radiopharmaceutical matches this procedure?

A

O-15 water

35
Q

Clinical app: cardiac- myocardial perfusion

Uptake mech: potassium analog

What’s this radiopharmaceutical?

A

Rb-82 Chloride

36
Q

Generator: decay product

What radiopharmaceutical is produced?

A

Rb-82 Chloride

37
Q

Inject, delay 90sec, image

What radiopharmaceutical matches this procedure?

A

Rb-82 Chloride

38
Q

Clinical app: cardiac- stress study

Uptake mech: blood flow

What’s this radiopharmaceutical?

A

N-13 Ammonia

39
Q

Irradiating purified water and 5% ethanol in cyclotron target

What radiopharmaceutical is produced?

A

N-13 Ammonia

40
Q

Inject, delay 2mins, image

What radiopharmaceutical matches this procedure?

A

N-13 Ammonia

41
Q

Clinical app: cardiac- rapid extraction, kinetic analysis

Uptake mech: fatty acid metabolism

What’s this radiopharmaceutical?

A

C-11 Palmitate

42
Q

CO-11^2 with Grignard reagent production of methyl iodide, Grignard reagent, and precursor

What radiopharmaceutical is produced?

A

C-11 Palmitate

43
Q

Clinical app: cardiac- myocardial perfusion imaging

Uptake mech: binds to mitochondrial complex 1

What’s this radiopharmaceutical?

A

F-18 Flurpiridaz

44
Q

nucleophilic substitution, similar to FDG

What 2 radiopharmaceutical are produced?

A

F-18 Flurpiridaz and F-18 Amyloid Florbetapir (Amyvid) Flutemetamol (Vizamyl) Flordetaben (Neuraceq)

45
Q

Inject at rest or stress, image after delay according to package insert

What radiopharmaceutical matches this procedure?

A

F-18 Flurpiridaz

46
Q

Clinical app: neurology- Parkinson’s disease

Uptake mech: dopaminergic system integrity

What’s this radiopharmaceutical?

A

F-18 FDOPA (6-(F-18)fluoro-L-dopa)

47
Q

F-18^2 gas and electrocyclic substitutions with precursor

What radiopharmaceutical is produced?

A

F-18 FDOPA (6-(F-18)fluoro-L-dopa)

48
Q

Fast, withdraw medications for Parkinson’s disease, pretreat with 150mg carbidopa, dynamic image

What radiopharmaceutical matches this procedure?

A

F-18 FDOPA (6-(F-18)fluoro-L-dopa)

49
Q

Clinical app: neurology- amyloid plaque imaging

Uptake mech: binding to beta-amyloid plaque

What’s this radiopharmaceutical?

A

F-18 Amyloid Florbetapir (Amyvid) Flutemetamol (Vizamyl) Flordetaben (Neuraceq)

50
Q

Inject, delay according to package insert, image for 10-20mins

What radiopharmaceutical matches this procedure?

A

F-18 Amyloid Florbetapir (Amyvid) Flutemetamol (Vizamyl) Flordetaben (Neuraceq)

51
Q

Clinical app: neurology- tau tangle imaging

Uptake mech: binding to tau tangles

What’s this radiopharmaceutical?

A

F-18 Tauvid

52
Q

Inject, delay for 80mins, image for 20min

What radiopharmaceutical matches this procedure?

A

F-18 Tauvid

53
Q

Clinical app: oncology- neuroendocrine tumor

Uptake mech: peptide receptor

What 2 radiopharmaceuticals do this?

A

Ga-68 DOTATATE and Cu-64 DOTATATE (Detectnet)

54
Q

Elution of Ga-68 from Ge-68/Ga-68 generator and complexing with a DOTA precursor

What radiopharmaceutical is produced?

A

Ga-68 DOTATATE

55
Q

Inject, delay for 60-90min, perform WB imaging

What radiopharmaceutical matches this procedure?

A

Ga-68 DOTATATE

56
Q

Radiolabeled by manufacturer by complexing with DOTA precursor and available as a single-dose vial

What radiopharmaceutical is produced?

A

Cu-64 DOTATATE (Detectnet)

57
Q

Inject, delay 90min, perform WB imaging

What radiopharmaceutical matches this procedure?

A

Cu-64 DOTATATE (Detectnet)

PET Study Guide Ed 3 (19 decks)

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