Chapter 2 Flashcards
Clinical app: oncology- prostate
cardiac-oxidative metabolism (quantitative perfusion)
Uptake mech: fatty acid that tracks Krebs cycle
What’s this radiopharmaceutical?
C-11 Sodium acetate
Produced by CO-11^2 with grignard reagent, methyl magnesium bromide in diethyl ether
What radiopharmaceutical is produced?
C-11 Sodium acetate
Oncology- 6hr fast, inject, dynamic or delay 5mins, image
Cardiac- usually in conjunction with O-15 water perfusion study
What radiopharmaceutical matches these procedures?
C-11 Sodium acetate
Clinical app: oncology- malignancy
Uptake mech: fatty acid metabolism (cell membrane)
What 2 radiopharmaceuticals does this pertain too?
C-11 Choline and F-18 Choline
Produced by CO-11^2 reacting with dimethylethanolamine
What radiopharmaceutical is produced?
C-11 Choline
Oncology- fast, inject, delay, 5min, image
What 3 radiopharmaceuticals matches this procedure?
C-11 Choline, F-18 Choline, and C-11 Palmitate
F-18 fluoromethyltriflate and subsequently reacting with dimethylethanolamine and column purification
What radiopharmaceutical is produced?
F-18 Choline
Clinical app: oncology-malignancy
cardiac- viability
neurology- glucose metabolism
Uptake mech: glucose metabolism
What’s this radiopharmaceutical?
F-18 FDG
F-18 nucleophilic synthesis with mannose triflate precursor (Hamacher, 1986)
What radiopharmaceutical is produced?
F-18 FDG
Oncology- fast, inject, rest, 60-120min image
Cardiac- fast, euglycemic clamp, image
Neurology- fast, inject, delay 30-60min, image
What radiopharmaceutical matches these procedures?
F-18 FDG
Clinical app: bone imaging
Uptake mech: PO^-4 ioc exchange with hydroxyapatite crystals
What’s this radiopharmaceutical?
F-18 Sodium Fluoride
Capture F-18 on carbonate anion column, elute with potassium carbonate
What radiopharmaceutical is produced?
F-18 Sodium Fluoride
Inject, delay 1-2hr, image
What radiopharmaceutical matches this procedure?
F-18 Sodium Fluoride
Clinical app: oncology- prostate
Uptake mech: amino acid transport
What’s this radiopharmaceutical?
F-18 Fluciclovine Axumin
Nucleophilic substitution
What 4 radiopharmaceuticals are produced?
F-18 Fluciclovine Axumin
F-18 Fluoroestradiol (FES) Cerianne
F-18 Piflifolastat Pylarify
F-18 Tauvid
Perform CT, inject and begin imaging at 4mins pelvis through skull
What radiopharmaceutical matches this procedure?
F-18 Fluciclovine Axumin
Clinical app: oncology- breast cancer recurrency
Uptake mech: estrogen receptor uptake
What’s this radiopharmaceutical?
F-18 Fluoroestradiol (FES) Cerianne
Slow injection (1-2min), delay 80 min, image
What radiopharmaceutical matches this procedure?
F-18 Fluoroestradiol (FES) Cerianne
Clinical app: oncology- prostate
Uptake mech: PSMA binding
What 2 radiopharmaceuticals is this?
F-18 Piflifolastat Pylarify and Ga-68 PSMA
Inject, 60min uptake, image pelvis through skull
What radiopharmaceutical matches this procedure?
F-18 Piflifolastat Pylarify
Chelation
What radiopharmaceutical is produced?
Ga-68 PSMA
Inject, delay 50-100mins, image pelvis through skull
What radiopharmaceutical matches this procedure?
Ga-68 PSMA