Chapter 1 Quiz Flashcards

1
Q

Which radionuclides are possible radioactive contaminants in the eluent of Rb82 generator?

-Sr82 and Sr 85
-Sr82 and Zr82
-Zr 82 and Zr85
-Sr82 and Sr87

A

Sr82 and Sr 85

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2
Q

Negative ion PET cyclotrons accelerate which of the following types of particles?

-Protons
-negatively charged hydrogen atoms
-negatively charge neutrons
-negatively charges protons

A

negatively charged hydrogen atoms

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3
Q

F18 labeled to glucose using a chemical method known as _____.

-electrophilic substitution
-base hydrolysis
-mannose triflate hydrolysis
-nucleophilic substitution

A

nucleophilic substitution

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4
Q

The bombarding particles used for the nuclear reactions that occur in a cyclotron must have an energy of at least ____MeV.

3
5
8
10

A

8

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5
Q

The most common irradiation process of producing F18 with a 109.7 minute half-life is ______.

O18 (p,alpha) F18
O16 (p,pn) F18
O16 (p,alpha) F18
O18 (p,n) F18

A

O18 (p,n) F18

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6
Q

According to the US federal regulations, any product with a half-life greater than ____ minutes must pass quality control testing before it can be released for human use.

10
20
30
60

A

20

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7
Q

As specified in the USP, F18-FDG must have chemical purity of greater than ____.
85%
90%
95%
98%

A

90%

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8
Q

Which of the following quality control tests for F18-FDG CANNOT be preformed before patient use?

radiochemical purity
radionuclidic purity
pH
sterility

A

sterility

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9
Q

The initial precursor molecule for producing F18-FDG is _____.

mannose triflate
dibutylboron triflate
trifluoroacetic acid
methyl triflate

A

mannose triflate

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10
Q

Because of the high amount of radioactivity, the production of PET radiopharmaceuticals must be done in lead-shielded hot cells and with an automated system called a ______.

cyclotron
synthesis module
reactor vessel
Kryptofix 222

A

synthesis module

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