Chapter 2 Flashcards
Prokaryote
Unicelluar, no membrane, bacteria
Eukayote
Multicellular and unicellular with membranes, DNA has tightly packed chromosomes, Genetic material forms a nucleus
virusus
Neither prokaryotic
nor eukaryotic
* Outer protein coat
surrounding nucleic
acid
Cell reproduction
Successful cell reproduction requires:
* Genetic information must be copied
* Copies must be separated from each other
* Cell must divide
Binary Fission
Simple division:
separation of replicated
circular chromosome
* Origin of replication
* Each new cell has an
identical copy of the
original chromosome.
Eukaryotic Cell Replication
DNA replication
* Copy separation
* Division of the cytoplasm
Nucleus internal scaffolding – nuclear
matrix
Homologous Pair
- Humans have 23 homologous pairs!
- The two chromosomes are usually alike in structure and size.
- Each carries genetic information for the same
set of hereditary characteristics (except sex
chromosomes
Ploidy
- Diploid cells carry two sets of genetic information.
- Haploid cells carry one set of genetic information
- Polyploid – cells that contain more
than two sets.
Diploid cells have
Two sets of chromosomes
Chromosome Structure
Centromere: attachment
point for spindle
microtubules
Pair of telomeres:tips of a linear
chromosome
Protect and stabilize the
chromosome ends.
Origin of Replicationn: where
the DNA synthesis begins (not
easily observed by
microscopy
Interphase
- G1
/S checkpoint: regulated decision point - S: DNA synthesis
- G2
/M checkpoint: passed if DNA is completely replicated and undamaged
M Phase and Cytokinesis
- Mitosis: separation of sister chromatids
- Cytokinesis: separation of cytoplasm
Counting Chromosomes
and DNA Molecules
1) # of chromosomes = # of functional centromeres!
2) # of DNA molecules
Determine if sister chromatids are present!
a) If sister chromatids are present
(chromosome has replicated), then the number of
DNA molecules is twice the number of chromosomes.
b) If absent, the DNA molecules count is the
same as chromosome!
Mitosis vs. Meiosis
Mitosis:
* Single nuclear division with typically a single cell division
* Same chromosome number in new cells as original
* Produces genetically identical cells
Meiosis:
* Two divisions
* New cells have half the number of chromosomes as original
* Produces genetically variable cells (crossing over)
Sexual Reproduction and
Genetic Variation
Meiosis: the production of haploid gametes
Fertilization: the fusion of haploid gametes
Genetic variation: consequences of meiosis