CHAPTER 19 Flashcards
its the Central metabolic pathway and plays a key roles in aerobic metabolism
Citric acid cycle
the electrons derived from oxidation of nutrients
are passed to oxygen
Electron transport
Oxidative breakdown of nutrients | simpler to complex molecule
Catabolism
Reductive synthesis of biomolecules | complex to simpler molecule
Anabolism
Also called Krebs cycle or tricarboxylic acid cycle (TCA cycle)
Amphibolic
where does Amphibolic takes place?
mitochondria
it is oxidized and transferred to a sulfur atom of the reduced form of lipoamide
Hydroxyethyl group (HE)
it is reduced to dihydrolipoamide
Lipoamide
allosteric
enzyme that inhibited by NADH, ATP & succinyl-CoA
is citrate achiral and has no stereocenter: T or F
True
Oxidative decarboxylation of isocitrate to form a-ketoglutarate and CO2 is catalyzed by:
Isocitrate dehydrogenase
Oxidative decarboxylation of α-ketoglutarate to form succinyl-CoA is catalyzed by:
a-ketoglutarate
dehydrogenase complex
Thioester bond of succinyl-CoA is hydrolyzed to produce succinate and CoA-SH is catalyzed by:
succinyl-CoA synthetase
Hydration of fumarate to form L-malate is catalyzed by:
fumarase
Malate is oxidized to oxaloacetate, and another molecule of NAD reduced to NADH is catalyzed by:
malate dehydrogenase
What is the gross ATP in glycolysis
4
Net ATP in glycolysis
2
Inhibited by ATP, NADH, succinyl CoA, and its
own product, citrate
Citrate synthase
Activated by ADP and NAD+ and inhibited by
ATP and NADH
Isocitrate dehydrogenase
Inhibited by ATP, NADH, and acetyl-CoA
Pyruvate dehydrogenase
Pathway in plants and some bacteria that is an alternative to the citric acid cycle
GLYOXYLATE CYCLE
Glyoxyalate cycle takes place in
Glyxosomes
Reaction that ensures an adequate supply of an important metabolite
Anaplerotic reaction
cannot be produced from acetyl-CoA in mammals
Pyruvate
the principal energy and carbon source in animals
carbohydrates
