Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Behavioral Neurosciencec 3801 > Chapter 18 - Drugs > Flashcards

Chapter 18 - Drugs Flashcards

1
Q

the removal or reduction of an aversive stimulus that is contingent on a particular response, with an attendant increase in the frequency of that response

  • A behaviour that turns off (or reduces) an aversive stimulus will be reinforced.
  • response makes unpleasant stimuli decrease/end
A

negative feedback

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

body’s attempt to compensate for unusual condition

– decrease in sensitivity to a drug that comes from repeated use

A

tolerance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

primarily the opposite of the effects of the drug

A

withdrawl symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

liking

A

hedonic value

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

wanting

A

positive-incentive value

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

anticipated pleasure associated with an action

A

positive-incentive value

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

amount of pleasure that is actually experienced.

A

hedonic value

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Animals are first trained to make a response (press a lever), that is reinforced by iv injections of drug (cocaine).
Response is extinguished – injections of saline instead of cocaine.
Once the animal stops responding (pressing the lever), experimenter administers a “free” injection of drug.
In response, animals begin pressing lever again.
- inhibition of dACC prevents reinstatement
- activation of vmPFC inhibits responding

A

reinstatement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

new form of learning, animal does not forget to make a particular response, it learns not to.

  • vmPFC plays critical role; stimulation of vmPFC with AMPA blocked reinstatement of responding normally produced by free shot of cocaine
  • activation of vmPFC inhibited responding
A

extinction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

involved in the behavioral effects of natural reinforcers

A

endongenous opiods

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

(blocks opiate receptors) reduce the reinforcing effects of alcohol in humans and rats.
- blocks u opiate receptors
antagonized the reinforcing and sedative effects

A

naloxone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

sudden withdrawal from long-term administration of a drug caused administration of an antagonistic drug

A

Antagonist-precipitated withdrawal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Potent DA agonists

A

cocaine and amphetamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

hallucinations, delusions of persecution, mood disturbances, repetitive behaviours

A

psychotic behaviours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

blocks CB1 receptors

A

Rimonabant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

One of the leading causes of mental retardation in the Western world.
Foetal development
Effects are most serious during last trimester and several years after birth.

A

FAS

17
Q

GABAa agonist, NMDA antagonist.

A

alcohol

18
Q

Partial agonist for the μ opiate receptor
- drug high affinity for receptor but, activates less than ligand.
decreases ligand effect in high concentration areas
increases in regions low concentrations
- blocks opiate effects
- produces weak effects

A

Buprenorphine

19
Q

Conjugated cocaine to a foreign protein which stimulated rats’ immune system to develop antibodies to cocaine
Prevented cocaine from passing BBB, less sensitive to activating effects of cocaine

A

immunotherapy

20
Q

antidepressant drug, catecholine reuptake inhibitor

- used for nicotine addiction

A

Bupropion

21
Q

partial agonist for the nicotinic receptor

A

Varenicline

22
Q

opiate antagonist

A

Naltrexone

23
Q

NMDA-receptor antagonist

A

Acamprosate

24
Q

GABAa receptor (indirect agonist)

A

barbituates or benzodiazepines

25
Q

CB1 cannabinoid receptor (agonist)

A

weed

26
Q

nicotinic ACh receptor (agonist)

A

nicotine

27
Q

um and delta receptors (agonist)

A

opiates (heroine, morphine)

28
Q

blocks DA reuptake

A

cocaine

29
Q

NDMA receptor (indirect antagonist)

A

PCP, Ketamine

30
Q

release DA - run DA transporter in reverse

A

amphetamines

31
Q

produced by unexpected dose of addictive drug.

involved activation of mesolimbic system of dopaminergic neurons

A

relapses

32
Q

area involved in suppresion of exctinction

A

vmPFC

33
Q

area involved in craving

A

dACC

34
Q

opatite receptors in preoptic area

A

hypothermia

35
Q

opiate receptors in recticular formation

A

sedation

36
Q

opiate receptors in PAG

A

analgesia

37
Q

opiate receptors in NAC and VTA

A

reinforcement

38
Q

damage to the _____ disrupts smoking addiction

A

insula

Behavioral Neurosciencec 3801 (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions