Chapter 17 Slide Set 3

Question 1

What can develop in the setting of celiac disease?

Answer 1

EATL

Adenocarcinoma

Question 2

FAP inheritence pattern?

What mutation?

Hypertrophy of what?

Answer 2

AD

APC

retinal pigment epithelium

Question 3

Clinical features of small bowel infarction and demographic?

Answer 3

Abdominal pain, bloody diarrhea, decreased bowel sounds

> 70 y/o, CAD

Question 4

What size of adenoma has 40% risk for cancer?

Answer 4

Greater than 4cm

Question 5

What is caused by a defect in lymphatic transport?

Answer 5

Whipped disease

Question 6

Transmural infarction of the small bowel occurs with thrombosis of what 2 structures?

Answer 6

SMA at splenic flexure

Mesenteric vein

Question 7

Which IBD is associated with PSC?

Answer 7

UC

Question 8

What are the 4 types of diarrhea?

Answer 8

Secretory
Osmotic
Malabsroptive
Exudate

Question 9

What kind of diarrhea is associated with lactase deficiency?

Answer 9

Osmotic (abates with fasting)

Question 10

MMR deficiency is seen with what age group?

What kind of adenoma?

Answer 10

Under 50

Sessile serrated adenoma

Question 11

What is the most common cause of obstruction worldwide?

Answer 11

Hernia

Question 12

Which IBD has risk for recurrence after surgery?

Malignant potential?

Answer 12

Crohn’s

UC

Question 13

What is the mutation in abetalipoproteinemia?

What stain?

Answer 13

MTP

Oil red-O

Question 14

Which IBD has broad-based ulcers, pseudopolyps, and mucosal bridges?

Risk for what

Answer 14

UC

Toxic megacolon

Question 15

What kind of obstruction presents in the LLQ and has increased tympanic sounds and distention?

Answer 15

Volvulus (twisting of a loop of bowel about its mesenteric point of attachment)

Question 16

In ischemic bowel disease with transmural infarction, what kind of pathologic finding is seen?

Answer 16

Coagulative necrosis of the muscularis propria with 1-4 days

Question 17

Gardner syndrome associated with what?

Answer 17

APC mutation

Osteomas, thyroid/Desmond tumor, skin cyst

Question 18

Dermatitis herpetiformis is seen in what disease?

What antibody?

Answer 18

Celiac disease

IgA anti-gluten Ab

Question 19

What is caused by a defect in intraluminal digestion?

Answer 19

Chronic pancreatitis

Cystic fibrosis

Question 20

Etiology of adhesions?

Answer 20

Acquired -> surgery, trauma, intra-abdominal infection, endometriosis

Question 21

What is diagnostic for celiac?

What HLA associations?

Answer 21

Tissue transglutaminase (tTG)

DQ2 or DQ8

Question 22

What type of polyp is the most common found in the left colon?

Most common when?

Answer 22

Hyperplastic

60-70

Question 23

What organism causes a pattern of neutrophils resembling volcanic crypts?

Causes what?

Answer 23

C. Diff

Pseudomembranous colitis

Question 24

What gene abnormality with autoimmune enteropathy?

Inheritence pattern?

Answer 24

IPEX due to FOXP3 mutation

X-linked

Question 25

What presents as only transepithelial transport abnormalities?

Answer 25

Abetalipoproteinemia

Question 26

What only presents with terminal digestion problems?

Answer 26

Autoimmune enteropathy

Question 27

Congenital lactase deficiency what inheritence?

Answer 27

AR

Question 28

What kind of polyps are associated with juvenile polyps and Peutz-Jeghers syndrome?

Answer 28

Hamartoma tous polyps

Question 29

What causes pencil thin stools?

Answer 29

Left sided colon cancer

Question 30

What is a rare AR disease characterized by inability to secrete triglyceride-rich lipoproteins? What histologic finding?

Answer 30

Abetalipoproteinemia Acantholytic red cell (Burr cell)

Question 31

What incidental tumor is commonly found during appendectomy? Describe it

Answer 31

Neuroendocrine tumor (Carcinoid) Bright Yellow, tan, well-circumscribed

Question 32

Gene mutation in UC?

Answer 32

ECM1 | HNFA

Question 33

Mean age of Peutz-Jeghers syndrome? Gene mutation? What extra-gi manifestation? Inheritence pattern?

Answer 33

10-15 STK11 Pigmented macules around face AD

Question 34

Hiv positive and HPV related problems of anus is most likely what?

Answer 34

Hemorrhoids

Question 35

HNPCC mutated gene? Inheritance pattern? Molecular defect? Location?

Answer 35

MSH2, MLH1 AD DNA MMR Right side

Question 36

What are the 2 most important prognostic factors in colon cancer?

Answer 36

``` Depth of invasion (T) # of nodes (N) ```

Question 37

Gene mutation in Crohn's?

Answer 37

NOD2 ATG16L1 IRGM

Question 38

What pathologic finding for IBS? Affects who?

Answer 38

NONE Females 20-40

Question 39

What kind of obstruction is the most common cause in kids under 2? Due to what?

Answer 39

Intussusception After viral infection or rotavirus vaccine

Question 40

Mean age of juvenile polypsosis? gene mutation? Risk of what?

Answer 40

< 5 SMAD4, BMPR1A, TGF-B Gastric, small intestine, colonic, pancreatic adenocarcinoma

Question 41

Which IBD disease is smoking protective for?

Answer 41

UC

Question 42

What is the most common malignancy of the GI tract?

Answer 42

Adenocarcinoma of the colon

Question 43

How do you diagnose intussusception?

Answer 43

Contrast enema

Question 44

Turcot syndrome associated with what?

Answer 44

APC mutation | Medulloblastoma, glioblastoma

Question 45

What is the most common cause of obstruction in the U.S.?

Answer 45

Adhesion

Question 46

Location of Crohn's disease? Morphologic features?

Answer 46

Skip lesions, Right colon, iléal Cecil valve Strictures, transmural inflammation, creeping fat, granulomas

Question 47

Which IBD puts at a risk for fistulae, perforation and colonic adenocarcinoma?

Answer 47

Crohn's