Chapter 17: Sleep Flashcards

1
Q

Is the brain active during sleep, despite being unconscious?

A

Yes, the brain remains active during sleep, and sleep is categorized into different stages, each characterized by distinct patterns of electrical brain activity.

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2
Q

What are the initial three stages of sleep grouped as, and what roles do they play?

A

The initial three stages are grouped as non-rapid eye movement (NREM) sleep. These stages play a crucial role in physical growth and repair, mental restoration, and memory consolidation.

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3
Q

What characterizes Stage I of NREM sleep?

A
  • a short transitional phase from wakefulness to sleep.
  • easily disturbed by outside stimuli
  • individuals may not be aware that they have fallen asleep.
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4
Q

What characterizes Stage II of NREM sleep, and what are sleep spindles and k-complexes?

A

Stage II is deeper than Stage I but still a light sleep. It is characterized by bursts of brain activity known as sleep spindles and k-complexes. Sleep spindles are suspected to be important for memory consolidation, and both sleep spindles and k-complexes block external stimuli, allowing for a deeper sleep.

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5
Q

What is Stage III of NREM sleep, and why is it considered essential?

A

Stage III represents the deepest sleep stage in the sleep cycle. It is essential for feeling well-rested and rejuvenated. During this stage, the body releases growth hormone and testosterone, contributing to recovery and restoration of bodily functions.

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6
Q

What are some physiological processes associated with Stage III of NREM sleep?

A

During Stage III, the body releases growth hormone and testosterone, contributing to the recovery and restoration of bodily functions. Tissues and structures undergo repair, supporting overall restorative functions.

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7
Q

What is REM sleep, and what are its distinct characteristics?

A

REM sleep is the final stage in the sleep cycle, typically following deep sleep stages. It is characterized by rapid movement of the eyes under closed lids, and it is when most dreaming occurs.

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8
Q

What happens to skeletal muscles during REM sleep?

A

Skeletal muscles are inhibited from contracting during REM sleep, preventing physical movements that may accompany dreams. This is to avoid acting out dreams physically.

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9
Q

What are some characteristics of REM sleep, such as increased brain activity and physiological changes?

A

During REM sleep, some regions of the brain become more active compared to other sleep stages. Despite the apparent restfulness, REM sleep is associated with increased blood pressure, respiration, and heart rate.

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10
Q

How do all four sleep stages occur in relation to each other, and how many times does a complete sleep cycle repeat throughout the night?

A

All four sleep stages occur consecutively, forming a complete sleep cycle. A sleep cycle repeats approximately 4 to 5 times throughout the night.

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11
Q

What is the optimal timing for a well-timed nap, and how can it contribute to feeling more refreshed and alert?

A

For a well-timed nap, set a timer for 90 minutes to coincide with the end of a sleep cycle. Waking up at the completion of a cycle helps in feeling more refreshed and alert.

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12
Q

What does the body prioritize early in the night, and when does the deepest sleep, including slow-wave sleep, tend to occur?

A

The body prioritizes deep restorative sleep early in the night in case of waking up. The deepest sleep, including slow-wave sleep, tends to happen at the beginning of the night.

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13
Q

What does the composition of the first cycle of a sleep cycle involve, and how long does an entire sleep cycle last?

A

The initial cycle involves progressing through the three stages of NREM sleep, followed by a period of REM sleep, which consistently serves as the final stage. The entire sleep cycle lasts approximately 90 minutes.

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14
Q

How do the duration of slow-wave sleep stages vary throughout the night, and what is associated with the latter part of the night in terms of sleep stages?

A

Slow-wave sleep stages are longer in the first part of the night, contributing to initial deep restorative sleep. The latter part of the night tends to have more REM sleep, which is associated with dreaming.

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15
Q

What is the circadian rhythm, and what role does the suprachiasmatic nucleus (SCN) play in regulating it?

A

The circadian rhythm is the natural, internal process that regulates the sleep-wake cycle and repeats roughly every 24 hours.

The suprachiasmatic nucleus (SCN) serves as the master clock that influences every cell’s sleep-wake pattern based on DNA.

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16
Q

what influences whether an individual is a “morning lark” or a “night owl,” and what external stimuli can impact the circadian rhythm?

A

Genetics play a role in determining whether an individual is a “morning lark” or a “night owl.” External stimuli, such as activities, exercise, eating patterns, and exposure to light, can influence the circadian rhythm.

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17
Q

How does exposure to light, especially in the morning, impact the circadian rhythm, and what adverse effects can occur with exposure to light late at night?

A

Exposure to light, especially in the morning, helps establish a routine wake-up time by prompting the SCN to set the internal clock. Exposure to light late at night can cause the SCN to reset, potentially delaying the sleep phase and disrupting the sleep-wake cycle.

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18
Q

What is the role of the pineal gland in sleep regulation?

A

The pineal gland, directly connected to the SCN, secretes melatonin at dusk, contributing to the initiation of the sleep phase.

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19
Q

how is melatonin secretion influenced by exposure to light?

A

regular exposure to morning light helps to establish a routine wake-up time.

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20
Q

What challenges might blind individuals face in regulating their sleep-wake cycles?

A

Blind individuals may face challenges due to the absence of light stimulation, disrupting the natural synchronization of the circadian rhythm.

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21
Q

what are some examples of circadian rhythm disruptions?

A

Circadian rhythm disruptions include jet lag, where an individual’s internal biological clock is out of sync with the time in a new environment, and delayed sleep phase, where a person stays up until 4 am and sleeps until noon.

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22
Q

What is the homeostatic sleep drive?

A

The homeostatic sleep drive is the body’s inherent tendency to regulate sleep in response to the balance between the amount of sleep an individual has had and the duration of wakefulness.

23
Q

how does the homeostatic it create a pressure or urge to sleep in response to wakefulness and the amount of sleep obtained?

A

It creates a pressure or urge to sleep that intensifies in relation to the time spent awake and the amount of sleep obtained.

24
Q

How does adenosine mediate the homeostatic sleep drive, and what role does it play in promoting sleepiness and a heightened desire to sleep?

A

Adenosine, a neurochemical in the brain, plays a crucial role in mediating the homeostatic sleep drive. The longer an individual stays awake, the more adenosine accumulates in the brain, promoting sleepiness and a heightened desire to sleep. Sleep helps clear adenosine from the brain, reducing the pressure to sleep and promoting wakefulness upon waking.

25
Q

How does sleep duration and quality change with age, and what sex differences exist in sleep patterns?

A

As individuals age, both the duration and quality of sleep tend to decrease. In the late twenties, there’s a decrease in deep sleep, and by the late forties, 60-70% of deep sleep is gone, further diminishing to 80-90% by the age of 70. Women tend to show less sleep disruption than men during these changes.

26
Q

What impact does aging have on wakefulness, sleep architecture, and restorative sleep?

A

Aging leads to increased sensitivity to external stimuli, making individuals more easily awakened. There is a transition in sleep architecture in the late twenties, with a progressive decline in deep sleep. Age reduces the time spent in restorative sleep, impacting the number, amplitude, and intensity of deep-sleep brain waves.

27
Q

How do sex differences manifest in sleep issues, including insomnia, snoring, and sleep apnea?

A

Women tend to report more instances of insomnia, while men report more incidents of snoring. Men are more likely to be diagnosed with sleep apnea. Women may experience sleep disruption due to hormonal changes during menstruation, menopause, and pregnancy.

28
Q

What is the relationship between sleep and mood, and how does sleep quality affect mental health?

A

Sleeping difficulty is often reported in those struggling with depression or mood disorders. Insomnia increases the risk for depression, and treating sleep problems can improve depression.

29
Q

what can poor sleep lead to?

A

Poor sleep can lead to increased irritability and emotional volatility, with adolescents showing more risk-taking behavior when sleep-deprived.

30
Q

How does sleep play a protective role in preventing cognitive decline, especially in relation to dementia and the glymphatic system?

A

The glymphatic system, active during sleep, clears waste products, including proteins like amyloids linked to Alzheimer’s. Sleep disruption is associated with an increased risk of developing dementia or causing it to manifest earlier.

31
Q

What is the glymphatic system, and how does it contribute to waste clearance from the brain during sleep?

A

The glymphatic system is a specialized waste clearance system in the brain that actively removes waste, including potentially harmful proteins, from the brain during sleep. It functions by increasing the flow of cerebral spinal fluid (CSF) by 90%, facilitating the efficient clearance of waste products.

32
Q

How does sleep impact athletic performance

A

Athletes who prioritize consistent and sufficient sleep may experience enhanced performance.

33
Q

what role do growth hormones and testosterone play in this context of athletic performance and recovery?

A

Insufficient sleep can lead to reduced levels of growth hormone and testosterone, compromising muscle health. Adequate sleep is essential for maintaining optimal levels of testosterone, directly linking sleep to athletic performance.

34
Q

How does poor sleep contribute to musculoskeletal pain, and what is the relationship between sleep and pain symptoms?

A

Poor sleep can increase the risk of developing musculoskeletal pain and reduce the pain threshold. Improving a patient’s sleep can, in turn, improve pain symptoms, although a challenge exists as pain may interfere with the sleep process, creating a feedback loop.

35
Q

What impact does sleep, or the lack thereof, have on obesity and weight management?

A

Lack of sleep is associated with overeating and weight gain. Ghrelin (the hunger hormone) rises, increasing appetite, while leptin (which makes us feel full) falls by 20-30% with sleep deprivation

36
Q

What does sleep deprivation activate?

A

Sleep deprivation also activates reward centers in the brain in response to food stimuli, leading to increased sugar and fat intake, heightened food appeal, and a tendency to be more fatigued and sedentary.

37
Q

How is cardiovascular disease linked to sleep, especially regarding sleep apnea and hypertension?

A

Sleep apnea, especially in individuals who snore, is robustly associated with hypertension, increasing the risk 2 to 3 times. Hypertension, in turn, is linked to various cardiovascular disorders, including cardiac arrest, strokes, and coronary heart disease.

38
Q

what risk is associated with a sleep duration of less than 6 hours?

A

Sleep duration less than 6 hours, especially in males, is associated with an elevated risk of mortality, further increased if individuals are hypertensive. The use of certain sleep medications is cautioned due to associations with higher mortality risk.

39
Q

How does sleep influence the risk of developing diabetes?

A

Lack of sleep is associated with insulin resistance, elevated cortisol levels, and impaired glucose metabolism. In males, shorter sleep duration doubles the risk of developing type II diabetes. Individuals experiencing difficulties falling asleep face a 50% higher chance of developing diabetes

40
Q

what is untreated sleep apnea linked to?

A

Untreated sleep apnea is linked to problems in glucose regulation, particularly impacting insulin’s ability to regulate glucose in young individuals.

41
Q

What is chronic insomnia?

A

Chronic insomnia is a condition characterized by difficulties in both falling and staying asleep.

42
Q

How is chronic insomnia characterized?

A

Individuals with chronic insomnia typically do not experience significant circadian rhythm disruptions, contrary to expectations, and often do not feel excessively sleepy during the daytime. Insomnia symptoms extend beyond nighttime difficulties, also encompassing trouble sleeping during the day.

43
Q

what percentage of North American adults exhibit symptoms associate with sleep apnea?

A

Approximately 30% of North American adults exhibit symptoms associated with insomnia.

44
Q

How is chronic insomnia treated?

A

a comprehensive evaluation to discover the cause of poor sleep, addressing issues like coughing, urination, anxiety, reflux, congestion, and other factors contributing to sleep disturbances.

45
Q

What are the criteria for diagnosing chronic insomnia

A

Chronic insomnia is diagnosed when sleep disruption occurs on at least three nights per week for a continuous three-month period.

46
Q

what does insomnia treatment emphasize?

A

avoidance of sleeping pills, establishing a consistent sleep routine, limiting daytime naps, creating a healthy sleep environment, and avoiding screen-based technology close to bedtime.

47
Q

How does exercise impact sleep?

A
  • Exercise is beneficial for sleep but should be avoided close to bedtime.
  • Exercise raises body temperature, exercising too close to bedtime may delay the cooling process, making it harder for the body to reach the optimal temperature for sleep.
  • Late-night exercise can stimulate the release of adrenaline and other stress hormones, leaving the nervous system in an alert state.
48
Q

what recommendations are provided regarding exercise for optimal sleep?

A

Recommendations include daily exercise (not close to bedtime) and avoiding screen-based technology to limit exposure to blue light.

49
Q

What is sleep apnea?

A

Sleep apnea results from a narrowed airway that becomes more obstructed during sleep, leading to interruptions in normal breathing patterns and brief pauses in breathing.

50
Q

what health conditions is sleep apnea linked to?

A

Sleep apnea is linked to serious health conditions, including hypertension, heart attacks, strokes, and negative impacts on diabetes, influencing glucose regulation and insulin sensitivity.

51
Q

Individuals with sleep apnea face an increased risk…

A

work-related and motor vehicle accidents due to daytime sleepiness and impaired alertness.

52
Q

what are potential indicators of sleep apnea?

A

Loud snoring and a family history of sleep apnea are potential indicators, prompting the need for a thorough assessment.

53
Q

What are the treatment options for sleep apnea?

A
  • lifestyle changes like weight loss, sleeping on the side, quitting smoking, and keeping nasal passages open.
  • Medical options include dental devices or CPAP machines to prevent airway collapse.
  • Surgery, such as tonsil or adenoid removal, is considered in severe cases when other interventions are ineffective.
54
Q

how can lifestyle modifications improve symptoms of sleep apnea?

A

Lifestyle modifications and effective treatment significantly impact overall quality of life, improving energy levels, mood, and cognitive function.