Chapter 17 exam 1 Flashcards
What is Homeostasis? (3)
- State of equilibrium in body
- Naturally maintained by adaptive responses
- Body fluids and electrolytes are maintained within narrow limits
Body fluids and electrolytes are maintained within narrow limits. Definition of…?
Homeostasis
Naturally maintained by adaptive responses. Definition of…?
Homeostasis
State of equilibrium in the body. Definition of…?
Homeostasis
Water content of the body weight in ADULTS is how much % ?
50 - 60%
Water content of the body weight in OLDER ADULTS is how much % ?
45 - 55%
Water content of the body weight in INFANTS is how much % ?
70 - 80%
Who has the most WATER CONTENT of the body? Adult, Older Adult, or Infant
Infant, 70 - 80%
Who has the least WATER CONTENT of the body? Adult, Older Adult, or Infant
Older Adult, 45 - 55%
Intracellular fluid (ICF) which takes place INSIDE the cell makes up how much of body fluid?
2/3 of body fluid
Extracellular fluid (ECF) which takes place OUTSIDE of the cell makes up how much of body fluid?
1/3 of body fluid
Intravascular (plasma) vs Interstitial fluid make up how much of Extracellular fluid (ECF)?
- Intravascular fluid makes up 1/3 of ECF
- Interstitial fluid makes up 2/3 of ECF
Substances whose molecules dissociate into ions (charged particles) when placed into water are…?
Electrolytes
Cations are positively (+) or negatively (-) charged?
Positively (+) charged
Anions are positively (+) or negatively (-) charged?
Negatively (-) charged
What is the type of measurement/ standard we use in the U.S. for Electrolytes?
Milliequivalent per liter (mEq)
mEq means…
Milliequivalent
What is the International standard of measurement for electrolytes?
Millimoles per liter (mmol/L)
Electrically charged particles are?
Ions
Sodium (Na), Potassium (K), Calcium (Ca2), Magnesium (Mg2) are examples of… Cations (+) or Anions (-) ?
Cations (+)
Bicarbonate (HCO3), Chloride (Cl), Phosphate (PO4) are examples of… Cations (+) or Anions (-) ?
Anions (-)
What are the PRIMARY prevalent Cation and Anions for Intracellular Fluid (ICF)?
Potassium (K+) & Phosphate (PO4 3-)
What are the PRIMARY prevalent Cation and Anions for Extracellular Fluid (ECF)?
Sodium (Na+) & Chloride (Cl-)
Another name for NaCl is? Table _______
Salt
6 Mechanisms for Controlling Fluid & Electrolyte Movement
- Diffusion
- Facilitated diffusion
- Active transport
- Osmosis
- Hydrostatic pressure
- Oncotic pressure
Normal serum level for anion, Bicarbonate (HCO3-) is _____?
22-26 mEq/L
Normal serum level for anion, Chloride (Cl-) is _____?
96-106 mEq/L
Normal serum level for anion, Phosphate (PO4 3-) is _____?
2.4- 4.4 mg/dL
Normal serum level for cation, Sodium (Na+)
135-145 mEq/L
Normal serum level for cation, Magnesium (Mg2+)
1.5-2.4 mEq/L
Normal serum level for cation, Calcium (Ca2+)
8.5-10.5 mg/dL
Does Solute dissolve into Solvent or does Solvent dissolve into Solute?
Solute dissolves into solvent. Ex. Sugar into water.
Movement of molecules from high to low concentration
- Occurs in liquids, solids, and gases
- Membrane separating two areas must be permeable to diffusing substance.
- Requires NO ENERGY
… is what type of mechanism for controlling Fluid & Electrolytes?
Diffusion
Movement of molecules from high to low concentration without energy
Uses SPECIFIC CARRIER molecules to accelerate diffusion
… is what type of mechanism for controlling Fluid & Electrolytes
Facilitated Diffusion
Process in which molecules move AGAINST concentration gradient
Example: sodium–potassium pump
External energy required (ATP)
… is what type of mechanism for controlling Fluid & Electrolytes
Active Transport
Movement of WATER between two compartments by a membrane permeable to water but not to solute
Moves from low solute to high solute concentration
Requires no energy
Note: WATER is moving and not SOLUTE
… is what type of mechanism for controlling Fluid & Electrolytes
Osmosis
In IMPORTANT ion is involved in Active Transport (ATP) ?
Phosphate
Amount of pressure required to stop osmotic flow of water is determined by….?
Concentration of solutes in solution
Theosmotic pressureis…
- minimumpressure needed to maintain equilibrium, with no net movement of solvent.
- It depends on themolar concentrationof the solute but not on what it is (e.g., sodium, glucose, etc.)
When you dissolve a solute in a solvent it makes a ________ ?
Solution
The pressure of osmosis is ______ pressure?
Osmotic Pressure
What are great big protein molecules that suck up all the water and have high oncotic pressure they pull water out of everything? Colloids or Cystalloids?
Colloids
Osmotic Pressure:
Osmolality vs. Osmolarity?
- Measure of the number of particles in the unit weight (e.g., Kg) of a SOLVENT
- Total volume of SOLVENT is precise, final volume of SOLUTION is not.
- MEASURED with an osmometer; typically a LAB value
- fluids INSIDE the body
- Examples: concentration of plasma, urine for diagnosing DM, dehydration, shock
Osmolality
Osmotic Pressure:
Osmolality vs. Osmolarity?
- Total mOsm of SOLUTE per unit of total volume of SOLUTION
- Total volume of SOLUTION is precise, final volume of SOLVENT is not. (e.g., Add solvent up to a final volume of 1 L.)
- CALCULATED based on solution contents; common bedside calculation in a clinical setting for osmotic activity
- fluids OUTSIDE of the body Ex. IV
- This value changes with Temperature & pressure (It’s difficult to estimate w/in a dynamic system.
Osmolarity
When you increase in pressure you increase in _____?
Temperature
Recall that _______ is that substance that is dissolved by SOLVENT in SOLUTION
Solute
Osmolality (Call me Al) takes place INSIDE or OUTSIDE the body?
Inside
Osmolarity (Call me Larry) takes place INSIDE or OUTSIDE the body?
Outside
The amount of sugar in urine is an example of Osmolality or Osmolarity?
Osmolality
Pressure from an IV fluid is an example of Osmolality or Osmolarity?
Osmolarity
of m0sm (Solute) divided by total Liters of solution is, and takes place outside of the body is Osmolality or Osmolarity?
Osmolarity
What is produced inside the body, in which you are measuring it? Osmolality or Osmolarity?
Osmolality
What type of solution has low energy on the outside of the cell that pulls fluid inside the cell making it bigger and bigger until it breaks (lysis)? Hypertonic, Isotonic, or Hypotonic
Hypotonic
What type of solution has high energy to pull fluid out of the cell? Hypertonic, Isotonic, or Hypotonic
Hypertonic
Fluids with same osmolality as the cell interior (equal distribution) are termed ____? Hypertonic, Isotonic, or Hypotonic.
Isotonic
_____ are syrups that pull fluid into them.
Colloid
Hydrostatic Pressure
- Force within a fluid compartment
- Major force that pushes water out of vascular system at capillary level
Oncotic Pressure
Osmotic pressure exerted by colloids in solution
- Protein is a major colloid
What type of IV Fluid is this? Colloid or Crystalloid
- Like syrup
- High osmotic pressure
- Contains large insoluble molecules that cannot pass through capillary -membranes
- Used to draw fluid from interstitial & intracellular spaces
- Disadvantage: allergic reaction
- Examples: albumin, blood, dextran, starches, gelatins
Colloid
What type of IV Fluid is this? Colloid or Crystalloid
- Like water
- Closest to ECF
- Used to expand intracellular and extracellular volume
- Can be isotonic, hypertonic, hypotonic
- Isotonic: expansion without altering plasma electrolyte concentrations
- Disadvantage: YOU CAN GET FLUID OVERLOAD
- Examples: NS, LR Saline
Cystalloid
What is the BIG difference between Crystalloids and Colloids?
Crystalloids are going to be thinner and Colloids are going to be thicker.
What two pressures cause the movement of water out of the capillaries?
Capillary hyrdrostatic pressure and interstitial oncotic pressure.
What two pressures cause the movement of fluid into the capillary?
Plasma oncotic pressure and interstitial hyrdostatic pressure.
At the venous end of the capillary, the capillary hyrdrostatic pressure is (LOWER or HIGHER) than oncotic pressure, and fluid is drawn back into the capillary by the oncotic pressure created by plasma proteins.
LOWER
At the arterial end of the capillary, capillary hydrostatic pressure ______ plasma oncotic pressure, and fluid is moved into the interstitium.
EXCEEDS
What has to happen in the fluid shift of plasma-to-interstitial (Blood to tissue)?
- Elevation of hydrostatic pressure
- Decrease in plasma oncotic pressure
- Elevation of interstitial oncotic pressure
- Results in edema
What has to happen in the fluid shift of Interstitial-to-plasma (Tissue to Blood)?
- Fluid drawn into plasma space with increase in plasma – osmotic or oncotic pressure
- Compression stockings
- Results in decrease of edema
What is the pressure that attracts water called?
Oncotic Pressure
Associated with symptoms that result from cell shrinkage as water is pulled into vascular system is… Water Defecit (increased ECF) or Water Excess (decreased ECF)
Water Defecit (increased ECF)
Develops from gain or retention of excess water is… (increased ECF) or Water Excess (decreased ECF)
Water Excess (decreased ECF)
What is First Spacing?
Normal distribution of fluid in ICF and ECF
What is Second Spacing?
Abnormal accumulation of interstitial fluid (edema)
What is Third Spacing?
Fluid accumulation in part of body where it is not easily exchanged with ECF
Regulation of Water Balance consists of?
- Hypothalamic regulation
- Pituitary regulation
- Adrenal cortical regulation
- Renal regulation
- Cardiac regulation
- Gastrointestinal regulation
- Insensible water loss
The ability to attract water is Hydrostatic pressure or Oncotic pressure?
Oncotic pressure
The ability to push water is Hydrostatic pressure or Oncotic pressure?
Hydrostatic pressure
What type of regulation of water consists of Osmoreceptors in hypothalamus sense fluid deficit or increase, stimulates thirst and antidiuretic hormone (ADH) release, and result in increased free water and decreased plasma osmolarity?
Hypothalamic Regulation
What type of regulation of water is Under control of hypothalamus, posterior pituitary releases ADH, and stress, nausea, nicotine, and morphine also stimulate ADH?
Pituitary Regulation
What type of regulation of water consists of;
Releases hormones to regulate water and electrolytes
Glucocorticoids
- Cortisol regulates water and electrolytes, conserves them
Mineralocorticoids
- Aldosterone
Adrenal Cortical Regulation
Factors affecting aldosterone secretion?
Check Fig. 17-9
Effects of stress on fluid an electrolyte balance?
Check Fig. 17-10
What type of regulation of water consists of;
Primary organs for regulating fluid and electrolyte balance
Adjusting urine volume
- Selective reabsorption of water and electrolytes
- Renal tubules are sites of action of ADH and aldosterone.
Renal Regulation
What type of regulation of water consists of;
Natriuretic peptides are antagonists to the RAAS.
- Produced by cardiomyocytes in response to increased atrial pressure
- Suppress secretion of aldosterone, renin, and ADH to decrease blood volume and pressure
Cardiac Regualtion
What type of regulation of water consists of;
- Oral intake accounts for most water.
- Small amounts of water are eliminated by gastrointestinal tract in feces.
- Diarrhea and vomiting can lead to significant fluid and electrolyte loss.
Gastrointestinal Regulation
What is Insensible Water Loss?
Invisible vaporization from lungs and skin to regulate body temperature
- Approximately 600 to 900 mL/day is lost.
- No electrolytes are lost.
What are some Gerontologic Considerations?
- Structural changes in kidneys decrease ability to conserve water.
- Hormonal changes lead to increase in ADH and ANP.
- Loss of subcutaneous tissue leads to increased loss of moisture. Skin gets thinner
- Reduced thirst mechanism results in decreased fluid intake. Lose moisture quicker
- Nurse must assess for these changes and implement treatment accordingly.
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Fluid and Electrolyte imbalances are common in most patient with…?
Common in most patients with major illness or injury