Chapter 17/21 Flashcards
what type of cells synthesize insulin in the pancreas
beta cells in the pancreas –> bring in glucose
When plasma glucose is high what happens to decrease this
high plasma glucose causes beta cells in the pancreas to increase insulin secretion –> decrease plasma glucose
What is diabetes mellitus
group of metabolic diseases characterized by an inability to produce enough insulin or use it properly
- characterized by hyperglycemia
explain what type 2 diabetes is
* explain the pathway and how it effects the muscle
- insulin sensititivity – downregulated
- sufficient insulin secreted into the blood stream –> increased glucose in the blood stream & obesity, inheritance and other factos leading to insulin resistance –> muscle unable to use glucose due to insulin resistance
- also increased glucose absorption with excess loss in the urine –> sweet urine –> kidney damage
explain what type 1 diabetes is
* explain the pathway and how it effects the muscle
- dont produce enough insulin
- low insulin secreted from the pancreas into the blood stream –> increased blood glucose due to low insulin & glycogen and protein breakdown causing keto-acidosis –> muscle unable to use glucose due to low insulin
- also increased glucose absorption with excess loss in the urine –> sweet urine –> kidney damage
What are the 6 signs and symptoms of diabetes
- polydipsia (excessive thirst)
- polyuria (frequent urination)
- unexplained weight loss
- infection and cuts that are slow to heal
- blurry vision
- fatigue
** flux b/t hypo and hyper glycemic**
will exercise help type 1 diabetes
help translocate GLUT 4 to bring glucose into the muscle cells == worried more about hypo-glycemia NOT hyperglycemia
what is the effect of prolonged exercise in diabetics
- control of glucose is important – if dont inject enough insulin before exercise == high in plasma glucose
what happens to type 1 diabetics who do not inject the adequate amount of insulin before exercise
increase in plasma glucose
What is the effect of plasma insulin concentration, liver glucose release, glucose uptake by muscle, and blood glucose concentration with normal insulin levels
- plama insulin concentration = normal or slightly decreased
- high liver glucose release
- high glucose uptake by muscle
- unchanged blood glucose concentration
What is the effect of plasma insulin concentration, liver glucose release, glucose uptake by muscle, and blood glucose concentration with hypoinsulinemia
- plasma insulin concentration = markedly decreased
- high liver glucose release
- lower glucose uptake by muscle
- small increase blood glucose concentration
What is the effect of plasma insulin concentration, liver glucose release, glucose uptake by muscle, and blood glucose concentration with hyperinsulinemia
- plasma insulin concentration = increased
- small increase liver glucose release
- very large glucose uptake by muscle
- small decrease blood glucose concentration
Does exercise alone control blood glucose in type I diabetics
NO does not alone control blood glucose
what is a major concern during exercise for type 1 diabetics
hypoglycemia – may result in insulin shock
- if take normal dose of insulin and exercsie –> both decrease blood glucose –> hypoglycemia
What chance can result in lowering the odds of exercise-induced hypoglycemia
regular exercise schedule
* intensity, frequency, and duration
* altering diet and insulin
at what blood sugar values should you avoid exercise and when should you ingest CHO
- if fasting glucose is >300 mg/dl
- ingest CHO if glucose is <100 mg/dl
What should you do to manage your blood sugar with exercise
blood glucose monitoring before and after exercise
* identify needed changes in insulin or food intake
* learn how blood glucose responds to different types of exercise
where should you inject insulin
away from working muscle –> prevent increased rate of uptake and hypoglycemia
interaction could cause hypoglycemia in that region
What is the primary treatment for type 2 diabetes
exercise is a primary treatment
* helps treat obesity
* helps control blood glucose and reduce insulin resistance
* helps treat CVD risk factors
combination of diet and exercise may eliminate need for diabetic drug treatment
may need to adjust med dosages when sedentary become trained – prevent hypoglycemia
Explains what happens to plasma glucose after ingesting glucose with no exercise, exercise, and control
- no exercise = highest reaction and increase in plasma glucose
- w/ exercise = lower spike in plasma glucose – more controlled
- control = small spike but for most part maintained
Explains what happens to plasma insulin after ingesting glucose with no exercise, exercise, and control
- no exercise = increases slowly and peaks at an hour an a half
- exercise = overall low plasma insulin and lower spike/release of insulin even than control
- control = spike early and then decrease over time
when there is a decrease in blood glucose with less insulin how is insulin sensitivity effected
more insulin sensitive
What is asthma
a respiratory problem characterized by shortness of breath and a wheezing sound
What is asthma due to
- contraction of smooth muscle of airways
- swelling of mucosal cells
- hypersecretion of mucus
- vasoconstriction of the bronchioles
How do you diagnose asthma
using a pulmonary-function testing
what does pulmonary function testing look at? What 2 variables
- Vital Capactity (VC) – max volume of air expelled after max inhalation
- forced expiratory volume (FEV1) – volume of air expired in 1 second during maximal expiration
What are the triggers of an asthma attack
allergens (dust, pollutants), exercise, stress
Explain the response once an asthma attack is triggered
- plasma cells produce IgE antibodies which attach to mast cells lining bronchial tubules
- mast cells release inflammatory mediators
what is exercise enduced asthma (EIA)? triggered by?
- caused by cooling and drying of respiratory tract – trigger release of chemical mediators and airway narrowing
- more common in asthmatics
- does not necessarily impair performance if medically controlled
how is exercise enduced asthma diagnosed?
make you run with strenuous running > or equal to 85-90% of maxHR
** if PFT test shows > or equal to 10% decrease in FEV1 indicates EIA (vasoconstriction or narrowing)**
Explain the influence of different sports on exercise enduced asthma
- not a large decrease in FEV1 % of pre-exercise value in asthmatic swimmers because they are breathing in high humidity air
- running has the greatest decrease in FEV1 %
What are 3 ways to prevent EIA
- warmup (15 min at 60% of VO2max)
- perform short-duration exercise
- use a mas or face mask in the cold weather
What are 2 treatments for EIA
- Beta2-agonist in case of attack during exercise (need higher dosage to effect credibility of racing) == Epinephrine binds to Beta-adrenergic receptor
- other medications to prevent attack
What is the influence on performance for Beta2-agonists
- inhaled Beta2-agonists do not improve performance
- ingested salbutamol (beta2-agonist) does improve strength, anaerobic power, and endurance (at 10-20x inhaled dose)
What is the leading cause of death from cardiovascular diseases
CAD
Explain the normal, elevated, and hypertension blood pressures
- normal: systolic <120mmHg and diastolic <80mmHg
- elevated: systolic b/t 120-129 and diastolic <80mmHg
- hypertension: stage 1 = systolic b/t 130-139mmHg OR diastolic b/t 80-89 mmHg stage 2 = systolic > or equal to 140mmHg OR diastolic > or equal to 90mmHg
What is the prevalence of hypertension in the US
- 1/3 of the U.S. adults
- hypertension increases with age
What is the effect of hypertension on the body? What 2 major effects
- damages the endothelium – predisposition for atherosclerosis (scar blood vessel - less elasticity and more plaque buildup) and other vascular pathologies
- increased afterload (high MAP) – lead to left ventricular hypertrophy that can lead to heart failure
What is the treatment for mild or borderline hypertension
- lose weight if overweight, limit alcohol, reduce sodium, eat diet rich in fruit, vegetables, low-dairy, reduced in saturated fat and cholesterol, stop smoking, exercise
What type of exercise is best for hypertension
- aerobic (b/c dont want spikes in BP) exercise on most or all days of the week
- moderate intensity for 30-60 min
Explain how strength changes in children with exercise
- strength increases as muscle mass increases with age
- peaks around 20 yrs. for women and 20-30 for men
- extend of muscular development depends on relative maturation of nervous system – if dont send signal to muscles the muscles will not grow
Explain thermoregulation in children during exercise
- children have increased surface area:mass ratio
- greater conductive heat loss, gain
- less evaporative heat loss (decreased sweat) – havent developed as much surface area to lose heat quickly
- slower heat acclimation (or acclimitization)