Chapter 163- Exanthematous viral diseases Part 2

Question 1

Common, self-limiting exanthem, with peak age of onset at ___, often due to viral infections

Answer 1

Gianotti-Crosti syndrome

1-6 years old

Question 2

Adult cases almost exclusively occur in women.

True or False

Answer 2

True

Question 3

Host risk factors associated with Gianotti Crosti syndrome (2)

Answer 3

Young age

History of atopic dermatitis

Question 4

Most common cause of GCS (2)

Answer 4

EBV

Hep B

Question 5

Bacterial pathogens associated with GCS (4)

Answer 5

M. Pneumoniae
Borrelia burgdorferi
Bartonella henselae
Group A beta hemolytic Streptococcus

Question 6

Most common accompanying symptom of GCS

Answer 6

Pruritus

Question 7

Cytomegalovirus is also known as

Answer 7

HHV5

Question 8

Major cause of hearing loss

Answer 8

Congenital infection

Question 9

Most common congenital viral infection in humans

Answer 9

Human cytomegalovirus

Question 10

Nearly all HIV-infected patients are infected with HCMV.

True or False

Answer 10

True

Question 11

Significant cause of morbidity in bone marrow transplant and solid organ transplant recipients

Answer 11

Human cytomegalovirus infection

Question 12

55% of maternal secondary HCMV infection of HCMV immune woman during pregnancy results in intrauterine infection of fetus.
True or False

Answer 12

False, maternal primary infection

Question 13

After congenital HCMV infection, approximately ___% of symptomatic and ___% of asymptomatic children have hearing loss

Answer 13

50%

10%

Question 14

Perinatal human CMV transmission occurs via (3)

Answer 14

Cervical secretions
Breastmilk
Blood transfusion

Question 15

Unlike EBV mononucleosis, HCMV mononucleosis do not have (3)

Answer 15

Pharyngitis
Lymphadenopathy
Heterophile antibodies

Question 16

Gold standard for diagnosis of HCMV

Answer 16

Viral culture from blood using human fibroblasts

Question 17

Identify primary infection in children younger than ___ months of age as they shed virus for long periods of time

Answer 17

12

Question 18

Most reliable method to determine past infection and is part of posttransplantation screening

Answer 18

HCMV IgG serology

Question 19

Most widely used test for diagnosis of CMV in immunocompromised patients

Answer 19

Quantitative nucleic acid amplification test

Question 20

Monitors response to trwatment for CMV

Answer 20

Quantitative nucleic acid amplification test

Question 21

Characteristic histologic feature of CMV

Answer 21

Owl’s eye cels (cytomegalic cells with nuclear inclusions)

Question 22

Uced for HCMV prophylaxis

Answer 22

Ganciclovir

Valacyclovir

Question 23

Causative agent of roseola infantum or sixth disease

Answer 23

HHV6

Question 24

HHV6 is common viral infection with up to ___% of population acquiring infection by 2 years old

Answer 24

80

Question 25

Cellular receptor for HHV 6 infection

Answer 25

CD46

Question 26

HHV6 reactivation is more common in solid organ transplantation than stem cell transplantation. True or False

Answer 26

False, stem cell more than solid organ

Question 27

Hallmark of exanthem subitum

Answer 27

Rose-colored macules and ppules surrounded by white halo

Question 28

Palpebral edema resulting in sleepy appearance and erythematous papules on soft palate

Answer 28

Nagayana spots

Question 29

Unique feature of roseola

Answer 29

Occurs 1 day before to 1-2 days after fever resolves

Question 30

Quantitative PCR does not distinguish laten from active infection of HhV6 True or False

Answer 30

Qualitative

Question 31

Most common complication of exanthem subitum

Answer 31

Febrile seizure without a rash

Question 32

In bone marrow transplant recipients, complications include (4)

Answer 32

Subacute encehalitis Bone marrow suppression Pneumonitis Thrombotic microangiopathy

Question 33

Prophylaxis treatment of HHV 6 infection with ganciclovir facilitates development of resistance. True or False

Answer 33

True

Question 34

MOT of HHV 7

Answer 34

Salivary

Question 35

Reactivation of HHV7 is more common than HHV6z. | True or False

Answer 35

True