Chapter 163- Exanthematous viral diseases Part 2 Flashcards
Common, self-limiting exanthem, with peak age of onset at ___, often due to viral infections
Gianotti-Crosti syndrome
1-6 years old
Adult cases almost exclusively occur in women.
True or False
True
Host risk factors associated with Gianotti Crosti syndrome (2)
Young age
History of atopic dermatitis
Most common cause of GCS (2)
EBV
Hep B
Bacterial pathogens associated with GCS (4)
M. Pneumoniae
Borrelia burgdorferi
Bartonella henselae
Group A beta hemolytic Streptococcus
Most common accompanying symptom of GCS
Pruritus
Cytomegalovirus is also known as
HHV5
Major cause of hearing loss
Congenital infection
Most common congenital viral infection in humans
Human cytomegalovirus
Nearly all HIV-infected patients are infected with HCMV.
True or False
True
Significant cause of morbidity in bone marrow transplant and solid organ transplant recipients
Human cytomegalovirus infection
55% of maternal secondary HCMV infection of HCMV immune woman during pregnancy results in intrauterine infection of fetus.
True or False
False, maternal primary infection
After congenital HCMV infection, approximately ___% of symptomatic and ___% of asymptomatic children have hearing loss
50%
10%
Perinatal human CMV transmission occurs via (3)
Cervical secretions
Breastmilk
Blood transfusion
Unlike EBV mononucleosis, HCMV mononucleosis do not have (3)
Pharyngitis
Lymphadenopathy
Heterophile antibodies
Gold standard for diagnosis of HCMV
Viral culture from blood using human fibroblasts
Identify primary infection in children younger than ___ months of age as they shed virus for long periods of time
12
Most reliable method to determine past infection and is part of posttransplantation screening
HCMV IgG serology
Most widely used test for diagnosis of CMV in immunocompromised patients
Quantitative nucleic acid amplification test
Monitors response to trwatment for CMV
Quantitative nucleic acid amplification test
Characteristic histologic feature of CMV
Owl’s eye cels (cytomegalic cells with nuclear inclusions)
Uced for HCMV prophylaxis
Ganciclovir
Valacyclovir
Causative agent of roseola infantum or sixth disease
HHV6
HHV6 is common viral infection with up to ___% of population acquiring infection by 2 years old
80
Cellular receptor for HHV 6 infection
CD46
HHV6 reactivation is more common in solid organ transplantation than stem cell transplantation.
True or False
False, stem cell more than solid organ
Hallmark of exanthem subitum
Rose-colored macules and ppules surrounded by white halo
Palpebral edema resulting in sleepy appearance and erythematous papules on soft palate
Nagayana spots
Unique feature of roseola
Occurs 1 day before to 1-2 days after fever resolves
Quantitative PCR does not distinguish laten from active infection of HhV6
True or False
Qualitative
Most common complication of exanthem subitum
Febrile seizure without a rash
In bone marrow transplant recipients, complications include (4)
Subacute encehalitis
Bone marrow suppression
Pneumonitis
Thrombotic microangiopathy
Prophylaxis treatment of HHV 6 infection with ganciclovir facilitates development of resistance.
True or False
True
MOT of HHV 7
Salivary
Reactivation of HHV7 is more common than HHV6z.
True or False
True
