Chapter 16: The Endocrine System Flashcards
Which hormone enhances reabsorption of calcium?
PTH
Which cells produce thyroglobulin from the thyroid gland?
Follicular cells
In both sexes, which gonadotropin stimulates the production of gametes?
FSH.
In the adrenal medulla, medullary chromaffin cells synthesize the catecholamines:
epinephrine and norepinephrine
Three types of stimuli trigger endocrine glands to manufacture and release their hormones.
Here’s one: Hormonal stimuli. Hormone release caused by another hormone (a tropic hormone). Example, hormones released from the hypothalamus tells the anterior pituitary to secrete hormones that stimulate other endocrine glands to secrete hormones.
- Humoral stimuli
Endocrine glands that secrete their hormones in direct response to changing blood levels of certain ions/nutrients. example: Low [Ca] in blood, Parathyroid glands secrete PTH to increase [Ca].
- Neural stimuli
Hormones released caused by neural input. Example: AP in preganglionic sympathetic fibers to adrenal medulla, the adrenal meduall cells secrete epinephrine and norepinephrine.
Which nuclei synthesize oxytocin?
Paraventricular nuclei
Supraoptic nuclei
Paraventricular nuclei
The thyrotropin-releasing hormone (TRH) triggers the release of [?}
TSH.
Which hormone increases basal metabolic rate and body heat production, regulating tissue growth and development, and maintaining blood pressure?
GH
TH
ACTH
Thyroid hormone
Thyroid stimulating hormone is stimulated by which releasing hormone?
Thyroid-releasing hormone.
The major target organ for glucagon is
The liver
Which hormone stimulates osteoclasts to digest bony matrix to release ionic calcium and phosphate to the blood due to falling blood calcium levels?
PTH
Ketones are acidic, and their build up in blood can cause [?]
Ketoacidosis
It can also cause ketonuria.
Gonadocorticoids secreted by the adrenal cortex are weak androgens, which are..
Male sex hormones
The parathyroid cells synthesize which hormone? Parathyroid cells are small and abundant, arranged in thick branching cords. Oxyphil cell’s function are unkown
PTH
Rising TH blood levels act on the pituitary and the [?] to inhibit TSH secretion.
Hypothalamus
Thymulin, thymosins, and thymopoetins are hormones to be involved in the development of [?] lymphocytes and immune response.
T lymphocytes
Elevated blood glucose levels stimulate release of [?], which decreases blood sugar levels, primarily by accelerating the transprot of glucose into the body cells, where it is oxidized for energy or converted to glycogen or fat for storage.
Insulin
Glucocorticoid
Glucagon
Insulin
cortisol (hydrocortisone), cortisone, and corticosterone is under which category of corticosteroids?
glucocorticoids
Prolonged exposure to high hormone concentrations can decrease the number of receptors for that hormone. This is called:
Up-regulation
Down-regulation
Down-regulation
(Desensitizing the target cells, so they respond less vigorously to hormonal stimulation, preventing them from overreacting to high hormone levels.
Which cells in the pancreas have an exocrine function?
Alpha-cells
Beta-cells
Acinar cells
Acinar cells
If anterior pituitary secretion is deficient in a growing child, the child will
A. develop acromegaly
B. become a dwarf but fairly normal body proportions
C. Mature sex at an earlier tahn normal age
D. Be in constant danger of becoming dehyrdated.
B.
When one hormone opposes the action of another hormone.
Permissiveness
Syngerism
Antagonism
Antagonism. Insulin lowers blood glucose levels, is antagonized by glucagon, which reasies blood glucose levels. Antagonisms may occur due to two hormones competing for the same receptor, act through different metabolic pathways, or a interaction between the two that causes down-regulation (progesterone/estrogen)
A hormone not involved in glucose metabolism is:
glucagon
cortisone
aldosterone
insulin
Aldosterone
When sugars cannot be used as fuel, as in DM, fats are used, causing [?]: high levels of fatty acids in blood.
Lipidemia
What are the two hormones the pancreas secretes?
Insulin and glucagon
The anterior pituitary is connected to the hypothalamus via [?] portal system
Hypophyseal portal system.
Containing primary capillary plexus
Hypophyseal portal veins
Secondary capillary plexus
Falling TH blood levels trigger release of [?].
TSH
Which hormone regulates the endocrine activity of the adrenal cortex?
Adrenocorticotropic hormone (ACTH)
Whish hormone that is produced by the ovaries, is responsible for maturation of the reproductive organs and the appearance of the secondary sex characteristics of females.
Estrogen
Progesterone
Estrogen
When glucagon targets the liver the breakdown of glycogen to glucose (called):
Glycogenolysis
Gluconeogenesis
glycogenolysis
When insulin is absent this result in type [?] Diabetes mellitus
1
Which area of the adrenal gland secretes aldosterone?
Adrenal cortex
What corticosteroid is known as the sex hormones?
mineralcorticoids
glucocorticoids
gonadocorticoids
Gonadocorticoids
The pituitary gland, also known as the [?], is located in the sella turcica of the sphenoid bone
Hypophysis
Pancreatic islets (langerhans), the endocrine portion of the pancreas. What are the two cells in the pancreatic islet?
Alpha-cells and Beta-cells
[?] are chemical messengers secreted by cells into the extra cellular fluids
Hormones
Which hormone is released in response to high blood calcium levels? Which gland secretes this hormone?
Calcitonin
Thyroid gland
Adrenocorticotropic hormone (ACTH), also known as corticotropin, is secreted by which cells in the anterior pituitary gland?
Corticotropic cells
Thyrotropic cells
Corticotropic cells
True/False: The anterior pituitary gland is also referred to as the master endocrine gland because it controls the activity of many other glands.
True
When more than one hormone produces the same effects at the target cell and their combined effects are amplified.
Permissiveness
Synergism
Antagonism
Synergism. Both glucagon and epinephrine cause the liver to release glucose to the blood. When they act together, the amount of glucose increases 150%
Which hormone promotes activation of viamin D, increasing absorption of calcium?
PTH
What is polyuria?
Excess urine output
Which cells produce glucagon? Where are these cells located?
Alpha-cells
Located in the pancreas (pancreatic islet)
Which zona produces glucocorticoids?
Zona fasciculata. The thickest part of the cortex. its cells are arranged in parallel cords or fascicles.
When the G protein is activated and moving along the membrane its binds to an effector enzyme. What is the enzyme called?
Adenylate Cyclase
Parathyroid hormone:
Increases bone formation and lowers blood calcium levels
Increases calcium excretion from the body
Decreases calcium absorption from the gut
Demineralizes bone and raises blood calcium levels
Demineralizes bone and raises blood calcium levels.
PTH is released when blood calcium levels are low
Target cell activation depends equally on three factors:
Here’s one: The blood levels of the hormone.
- The number of receptors for that hormone
- Affinity of the binding between the receptor and hormone
Elevated blood potassium levels stimulates which adrenocortical hormone?
Mineralocorticoid
Decreasing blood volume / pressure is also a stimulant.
The hypothalamic-hypophyseal tract connects the thalamas to the [?]
Posterior pituitary lobe
FSH and LH regulate the function of [?]
Gonads (ovaries and testes)
The most common condition when it comes to hypersecretion of TH is:
Myxedema
Goiter
Grave’s disease
Cretinism
Grave’s disease
An autoimmune disease. A person makes anitbodies directed against thyroid follicular cells. Rather than marking these cells for destruction as antibodies normally do, these antibodies paradoxically mimic TSH and continuously stimulate TH release. Typical symptoms: sweating, rapid/irregular heartbeat, nervousness, weight loss (high metabolic rate), opthalmos (protruding eyeballs).
Most T4 and T3 bind to [?-?] globulins (TBGs)
Thyroxine-binding globulins
Which gland is a small, cone-shaped gland located in the roof of the third ventricle of the brain?
Pineal gland
Which cells in the thyroid produce calcitonin?
Follicular cells
Parafollicular cells
Parafollicular cells
When a hormone binds to its receptor protein, the receptor activates a G-protein when which energy is attached?
ATP
GTP
GDP
GTP
[?] travel through blood and regulate metabolic function of other cells in the body.
Hormones
Autocrines
Paracrines
Hormones
Major metabolic hormone(s) of the body
TH (T4 and T3)
Overgrowth of hands, feet, and the face is due to a hypersecretion of GH. The conditions is known as
Gigantism
Acromegaly
Pituitary dwarfism
acromegaly.
Which enzyme phosphorylates various proteins during the second-messenger mechanism?
Adenylate cyclase
Protein kinase
cAMP
Adenylate cyclase
Prolactin-inhibiting hormone (PIH) known as dopamine, prevents which hormone secretion?
Prolactin
The outer cortex of the adrenal gland is divided into three areas or regions. which one produces aldosterone (mineralocorticoids)?
Zona fasciculatat
Zona glomerulosa
Zona reticularis
Zona glomerulosa
Hyposecretion of TH in infants leads to this condition:
Myxedema
Goiter
Grave’s disease
Cretinism
Cretinism
The child becomes mentally disabled, disproportionately sized body and thick neck and tongue.
Which gland is this?
Adrenal gland
The endocrine system influences metabolic activities via
hormones
Which area of the adrenal gland develops from neural crest tissue and is directly conrolled by the sympathetic nervous system?
Adrenal cortex
Adrenal medulla
Adrenal medulla
Proinsulin is where which hormone is derived from?
Insulin
What are the four tropic hormones the adenohypophysis secretes?
Follicle-stimulating hromone (FSH)
Adrenocorticotropic hormone (ACTH)
Thyroid-stimulating hormone (TSH)
Luteinizing hormone (LH)
Important anabolic hormone; many of its effects mediated by IGFs
Growth hormone
A lack of Iodine can cause this condition:
Myxedema
Goiter
Grave’s disease
Cretinism
Goiter
Enlarged protruding thyroid gland. The pituitary secretes increasing amounts of TSH to stimulate the thyroid to produce TH, but the only result is an accumulation of colloid.