Chapter 15 Flashcards
What is an immunogenicity?
An antigen that is recognized and elicits an immune response
What is humoral immunity?
An arm of adaptation immunity
Works to eliminate extracellular antigens
Mediated by B-lymphocytes aka B-cells-WBC
Develop in bone marrow and mature there as well
Gather in secondary lymphatic organs
Goal: make antibodies to help fight infection
Immature?
Antigen-specific receptor; not developed
Naive?
Have an antigen-specific receptor (not in contact with an antigen)
Activated?
Antigen is bound to the antigen-specific receptor (cell proliferated)
Effector?
Descendants of activated lymphocytes (produce substances)
Memory?
Long-lived descendants of activated lymphocytes (that can quickly became activated)
What is an antigen?
molecule recognized as foreign by the body ( recognition by antibodies or lymphocytes)
Explain Clonal Selection and Expansion Theory.
Body is prepared for infinite amount of antibodies; since there are an infinite amount off antigens out there
MHC?
Major Histocompatibility Complex Molecules;
MHC1= any cell w/nucleus
MHC2= WBC w/ T-Helper cells
MHC3= secreted proteins
Virus removes MHC1 cells and then the cell can’t call for help; backup is NK
Natural Killer cells?
Kill cells without MHC1 molecules; backup to prevent spreading
Antibody?
Glycoproteins (immunoglobulins)
Produced by B-cells (plasma cells)
Y shaped molecules or proteins
Actually 4 chains; 2 light and 2 heavy
What are the classifications of antibodies?
IgG- most abundant in blood IgA- most abundantly produced IgM IgE IgG
Opsonization?
Signal for eating; antibodies can work as the zipper
Complement?
Helps w/ inflammation, lyse, foreign cells, and opsonization
