Chapter 14 Flashcards
What are the categories for the first line of defense for innate immunity?
A. Physical Barriers= skin, mucus membrane
B. Anti microbial substances=
lysozyme=breaks down peptidoglycan (G+)
i.e. tears
Defenses= pores in bacterial i.e. mucus membrane
Lactoferrin= sequesters of iron i.e. saliva, mucus
Transferrin= ….. i.e. blood
Normal Flora (micro flora)
What are the cells of the immune system?
-blood cells= formed in bone marrow
-White Blood Cells: neutrophil=phagocytes, lymphocytes=several types
microphages=phagocytes
What is Cell Communication?
Immune “war” must know what’s going on
What are the three methods of cell communication?
- Cell surface receptors
- Cytokines
- Adhesion Molecules
What are the pattern recognition receptors? Describe.
- Toll-like receptors
- NOD-like receptors
- Rig-like receptors
What do s RLR detect from DNA?
dsRNA that belongs to the viruses
What do interferons do when a cell is infected?
Informs the cells about containing virus and prepares to kill with iAVP to AVP
suicide pill
What is apoptosis?
programmed cell death; cell suicide
What is the complement system of the innate immunity?
It complements antibodies; initiates inflammation, opsonization, and lysis of foreign cells.
What is opsonization?
Signal for phagocytosis; eating
What is Innate Immunity?
Nonspecific
What is phagocytosis?
Several stops; “zippering”
Zippering occurs because of
What is inflammation?
“Helps” contain site of damage; localize response and restore tissue function
Adhesion molecules grab on
What is fever of the innate immunity?
Not a good growth temperature for most human pathogens; increases rate of body defenses
