Chapter 14: the citric acid cycle Flashcards
The substrates and products of the pyruvate dehydrogenase complex (PDC) reaction
What type of reaction the PDC reaction is
Where in the cell the PDC reaction occurs?
What metabolic pathways are linked by the PDC reaction?
The names of the five cofactors required by PDC
Which coenzymes are catalytic and why they are called like that
Which coenzymes are co-substrates and why they are called like that
What is going on in the 5 steps of the PDC reaction
Role of FAD in the PDC reaction
Role of NAD+ in the PDC reaction
What are the effects of acetyl-CoA and NADH in the activity of PDC?
Other names of the citric acid cycle
Compound that feeds the cycle, where it does come from and what happens to it in the cycle
The energy products of the cycle
Type of reaction for each step of the cycle and understand what’s going on in each step
Reaction 1:
Reaction 2:
Reaction 3: CO2 is lost. This reaction is a oxidative decarboxylation. The secondary alcohol is being converted to a ketone. The substrate is oxidized and NAD+ is reducied to NADH.
Reaction 4: Another example of oxidative decarboxylation. It is thel loss of 2nd CO2. The oxidation is taking place in the carbon and it is becoming a sulfur. This is the second reaction that froms NADH.
Reaction 5: “substrate level” phosphorylation of GDP. Known as this when ATP is not used. Forming energy in thr form of GDP.
Reaction 6: oxidation of substrate generates QH2 (uniquinol)
Reactoin 7: Hydration of substrate. The additon of water across the double bond.
Reaction 8: Oxidation of malate regenerating oxalocetate.