Chapter 14 - Stomach Flashcards
Which arteries supply blood to the stomach?
The celiac artery, give rise to three major branches including the left gastric, splenic and common hepatic arteries.
Blood is drained from the stomach via the ____ vein.
portal
What are the primary functions of the stomach?
- Digestion of food (by mixing and breakdown of food by contraction and relaxation of the muscle layers in the stomach as well as secretion of stomach enzymes and acids)
- Temporary storage for food and regulation of entry into duodenum
The mucosa contains 3 types of glands which differ from one region of the stomach to another. Can you name all three?
- Cardiac gland (distal to GOJ)
- Oxyntic gland (proximal 2/3 of the stomach)
- Pyloric gland (antrum and pylorus)
What does the cardiac gland secrete?
mucus and pepsinogen
What does the cells of oxyntic gland secrete?
Chief cells secrete pepsinogen
Parietal cells secrete hydrochloric acid (HCL) and intrinsic factors necessary for absorption of vitamin B12
Enterochromaffin cells secrete serotonin
Gland also secrete bicarbonate and hormonal products eg. somatostatin and glucagon
Note: HCL converts pepsinogen to pepsin
What does the pyloric glands secrete?
Mucus cells secrete mucus and pepsinogen
G cells secrete gastrin
Enterochromaffin cells secrete serotonin
Gland also secrete bicarbonate and hormonal products eg. somatostatin and glucagon
When the normal balance between factors that promote mucosa injury (eg. gastric acid, pepsin) and those that protect (eg. mucus, bicarbonate) is upset 😡 this gives rise to ___ or ___.
inflammation or ulcers
What are some risk factors for peptic ulcers?
- H. pylori infection 🧫
- Chronic use of NSAIDs
- Family history
- Cigarette smoking 🚬
- Excessive acid production seen in Zollinger-Ellison syndrome
- Prolong use of corticosteroids
What is dyspepsia?
Epigastric discomfort, burning or pain
Can inflammation and edema of the ulcer in the antrum or scarring at the gastroduodenal junction cause gastric outlet obstruction?
Yes, because of impaired antral motility.
Can gastric ulcer be malignant?
Yes
What are some drug therapy for ulcer without H.pylori?
- PPI (decrease acid production)
- H2 blockers (decrease acid production)
- Sucralfate (forms a protective cover)
- Antacids (neutralizes gastric acid)
- Prostaglandins (antisecretory effects)
If peptic ulcers are left untreated this may cause
hemorrhage, perforation, penetration and obstruction
When there is uncontrolled hemorrhage from a gastric ulcer, what emergency surgery can be performed?
- Vagotomy with pyloroplasty
- Billroth I
- Billroth II
- Total gastrectomy
- Gastric resection