Chapter 13 Regulation Of Gene Expression Flashcards
Gene regulation
Is the turning on and off of genes
Gene expression
Is the over process of information flow from genes to proteins
Why is that gene expression has to be regulated?
The control of gene expression allow cells to produce specific kinds of proteins when and where they are needed
Gene regulation can help organism respond to environmental changes
Almost all of the cells on the organism contain:
An identical genome
Only a _ of theses genes are used or expressed in each cell
Fraction
The difference between cells types are not due to the presence of different genes but instead due to selective gene expression
True
Differentiation
The normal process by which a less specialized cell develop or matures to the possess a more distinct form and function
Differentiation is controlled by turning specific sets of genes on or off
T
Levels of gene expression control
Chromatin structure Transcriptional structure Post transcriptional control Translational control Post translational control
Euchromatin
Loosely coiled DNA accessible to RNA polymerase
Transcriptionally active
Heterochromatin
Tightly packed DNA inaccessible to RNA polymerase
Transcriptionally inactive
DNA coiling and packing affect gene expression.
More tight packed less Likely to be transcribed
Barr body
An inactive X chromosome
Gene mutation
Is a permanent Change in the sequence of bases in DNA
Germ line mutation
Occurs in sex cells
Somatic mutation
Occurs in body cells
Spontaneous mutations
Replication errors
DNA polymerase proofread
Induced mutation
Cause by mutagens such as radiation and chemical
Many mutagens are also carcinogens ( cancer causing )
Point mutation
Involves a change in a single DNA nucleotide Change one codon to a different codon Effect on protein vary Nonfunctional Reducing functionality Unaffected
Frame shift mutation.
Nucleotides are either inserted or deleted from DNA
The protein is always a a different protein usually no function
Silent mutation
No amino acids change no change in protein
Missense mutation
Changes the amino acid producing a different proteins
Nonsense mutation
Changes the amino acid into a stop codon producing short protein usually no function
Proto-oncogenes
Stimulate cell division