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Heme and Lymph Midterm > Chapter 13 Diseases of White Blood Cells Genes, Markers, and Proteins > Flashcards

Chapter 13 Diseases of White Blood Cells Genes, Markers, and Proteins Flashcards

1
Q

B-cell acute lymphoblastic leukemia/lymphoma

A

RUNX1
ETV6
PAX5, E2A, EBF

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2
Q

T-cell acute lymphoblastic leukemia/lymphoma

A

NOTCH1

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3
Q

Burkitt Lymphoma

A

MYC Ig loci

failed to express BCL2

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4
Q

Diffuse Large B-Cell Lymphoma

A

BCL6 (30%)
BCL2 (10%)
MYC (5%)

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5
Q

Extranodal Marginal Zone Lymphoma

A

MALT1-IAP2
BCL10-IgH
MALT1-IgH

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6
Q

Follicular Lymphoma

A

BCL2-IgH fusion gene

MLL2 gene

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7
Q

Hairy Cell Leukemia

A

BRAF mutations

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8
Q

Mantle Cell Lymphoma

A

Cyclin D1-iGh fusion gene

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9
Q

Small lymphocytic lymphoma (SLL) and Chronic lymphocytic lymphoma (CLL)

A

trisomy 12

deleted 11q, 13q, 17p

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10
Q

Adult T-cell leukemia/lymphoma

A

HTLV-1

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11
Q

Anaplastic Large-cell lymphoma

A

ALK rearrangement

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12
Q

Large Granular Lymphocytic Leukemia

A

STAT3 point mutation

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13
Q

Multiple Myeloma

A 
Ig heavy chain Chr 14q32
cyclin D1 on Chr 11q13
cyclin D3 6p21
17p deletion for TP53
LATE STAGE--MYC
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14
Q

Acute myeloid leukemia

A 
RUNX1
CBFB
RARa
PML-RARa
FLT3
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15
Q

Chronic Myelogenous Leukemia

A

BCR-ABL

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16
Q

BCR-ABL protein

A

Chronic Myelogenous Leukemia

17
Q

Retinoic Acid Receptor- PML

A

Acute Myeloid Leukemia, M3

18
Q

c-MYC

A

Burkitt’s Lymphoma

19
Q

BCL-2

A

Follicular Non Hodgkin’s Lymphoma

20
Q

H. Pylori Maltoma

A

Marginal Non Hodgkins

21
Q

Cyclin D1

A

Mantle Non Hodgkin’s

Heme and Lymph Midterm (8 decks)

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