Chapter 13 Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus Translocations

Question 1

immature neoplasm of B-Cell Acute lymphoblastic leukemia/lymphoma translocation

Answer 1

t(12;21)

Question 2

mature neoplasm Burkitt Lymphoma translocation

Answer 2

t(8;14)
Ig kappa t(2;8) light chain loci
Ig gamma t(8;22) light chain loci

Question 3

mature neoplasm Extranodal Marginal Zone Lymphoma translocations

Answer 3

t(11;18)
t(1;14)
t(14;18)

Question 4

mature neoplasm Follicular lymphoma translocation

Answer 4

t(14;18)

Question 5

mature neoplasm Mantle Cell Lymphoma

Answer 5

t(11;14)

Question 6

Diffuse Large B-Cell Lymphoma translocation

Answer 6

t(14;18)

Question 7

Multiple Myeloma translocation

Answer 7

t(4;14) = aggressive course

13q deletions = good outcome

Ig Heavy chain gene on Chr 14q32 translocates commonly with the following: cyclin D1 Chr 11q13 and cyclin D3 on Chr 6p21

Question 8

Acute Myeloid Leukemia translocation involvement

Answer 8

t(8;21) = favorable
inv(16) = favorable
t(15:17) = intermediate
t(11q23;v) = poor

Question 9

9:22

Answer 9

Chronic Myelogenous Leukemia

Question 10

15:17

Answer 10

Acute Myeloid Leukemia, M3

Question 11

8:14

Answer 11

Burkitt’s Lymphoma

Question 12

14:18

Answer 12

Follicular Lymphoma

Question 13

11:18

Answer 13

Marginal Non Hodgkin’s

Question 14

11:14

Answer 14

Mantle Non Hodgkin’s