Chapter 12 - Disorders Of Hemostasis Flashcards
The sticky part of blood is what?
The platelets sticking together
What is Thrombosis?
The inappropriate formation of clots within the vascular system
Von Willebrand (vWF) factor is generated by what?
Vessel endothelium
Clotting factors synthesized in the ________ using _______________
Liver Vitamin K
How do we get Vitamin K?
We ingest it in our diet ( mostly green foods) Ex: massive GI bleed from lack of Vitamin K in the diet
Vitamin K helps with what?
Helps clotting happen!!
Why is the 1st step of injury Vessel spasm (vasoconstriction)?
Our body’s do this to reduce the amount of blood loss - occurs in under 1 minute
What is another name for Factor VIII
Factor 8
TXA causes what to happen?
Causes blood to clot * will seen used more in hemolytic & severe cases
Aspirin doesn’t do what? (Common misconception)
Doesn’t thin blood (NOT a blood thinner)
Aspirin does what?
It prevents platelets from sticking together
Clotting cascade in located where?
In the Liver
What are examples of Anticoagulant drugs?
- Warfarin - Heparin
Anticoagulant drugs such as Warfarin & Heparin are used for what?
To prevent thromboembolic disorders
What is another name for Warfarin?
Coumadin
Warfarin alters ____________ so it can not assist with platelet coagulation
Vitamin K * Warfarin is prolonging clotting. Eating Vitamin K (ex: salads) is counteracting Warfarin by causing your blood to clot faster
How long does it take for Warfarin to reach its maximum effect?
36-72 hours (3 days) * with someone with an active blood clot, we essentially want to cover all bases and give heparin for a few days until the Warfarin has fully kicked in/ reached its maximum effect
What is it called when a blood clot breaks apart?
Embolism
What is it called when a blood clot stays together?
Thrombis…?
Warfarin & Heparin are both anticoagulants. What are the differences between the two?
Heparin works immediately WHEREAS Warfarin takes 3 days to work
What is TPA?
Tissue plasminogen activator
What does TPA do?
Is a protein involved in the breakdown of blood clots (Dissolves the clot)
Which type of thrombi is more severe? - Arterial thrombi or Venous thrombi-
Arterial thrombi Because: when an arterie is occluded, there is no oxygen, nutrients,etc. getting to that area of the body (ex: a limb) resulting in loss of a limb
Why are Venous thrombi not as detrimental as Arterial thrombi?
If a vein is occluded, the blood going back to the heart will just take a different pathway. (In the same sense as a traffic jam and having to take an alternate route)
Purple color on skin = _________?
Modeling (No oxygen to the area)
