Chapter 12 - Disorders Of Hemostasis

Question 1

The sticky part of blood is what?

Answer 1

The platelets sticking together

Question 2

What is Thrombosis?

Answer 2

The inappropriate formation of clots within the vascular system

Question 3

Von Willebrand (vWF) factor is generated by what?

Answer 3

Vessel endothelium

Question 4

Clotting factors synthesized in the ________ using _______________

Answer 4

Liver Vitamin K

Question 5

How do we get Vitamin K?

Answer 5

We ingest it in our diet ( mostly green foods) Ex: massive GI bleed from lack of Vitamin K in the diet

Question 6

Vitamin K helps with what?

Answer 6

Helps clotting happen!!

Question 7

Why is the 1st step of injury Vessel spasm (vasoconstriction)?

Answer 7

Our body’s do this to reduce the amount of blood loss - occurs in under 1 minute

Question 8

What is another name for Factor VIII

Answer 8

Factor 8

Question 9

TXA causes what to happen?

Answer 9

Causes blood to clot * will seen used more in hemolytic & severe cases

Question 10

Aspirin doesn’t do what? (Common misconception)

Answer 10

Doesn’t thin blood (NOT a blood thinner)

Question 11

Aspirin does what?

Answer 11

It prevents platelets from sticking together

Question 12

Clotting cascade in located where?

Answer 12

In the Liver

Question 13

What are examples of Anticoagulant drugs?

Answer 13

• Warfarin - Heparin

Question 14

Anticoagulant drugs such as Warfarin & Heparin are used for what?

Answer 14

To prevent thromboembolic disorders

Question 15

What is another name for Warfarin?

Answer 15

Coumadin

Question 16

Warfarin alters ____________ so it can not assist with platelet coagulation

Answer 16

Vitamin K * Warfarin is prolonging clotting. Eating Vitamin K (ex: salads) is counteracting Warfarin by causing your blood to clot faster

Question 17

How long does it take for Warfarin to reach its maximum effect?

Answer 17

36-72 hours (3 days) * with someone with an active blood clot, we essentially want to cover all bases and give heparin for a few days until the Warfarin has fully kicked in/ reached its maximum effect

Question 18

What is it called when a blood clot breaks apart?

Answer 18

Embolism

Question 19

What is it called when a blood clot stays together?

Answer 19

Thrombis…?

Question 20

Warfarin & Heparin are both anticoagulants. What are the differences between the two?

Answer 20

Heparin works immediately WHEREAS Warfarin takes 3 days to work

Question 21

What is TPA?

Answer 21

Tissue plasminogen activator

Question 22

What does TPA do?

Answer 22

Is a protein involved in the breakdown of blood clots (Dissolves the clot)

Question 23

Which type of thrombi is more severe? - Arterial thrombi or Venous thrombi-

Answer 23

Arterial thrombi Because: when an arterie is occluded, there is no oxygen, nutrients,etc. getting to that area of the body (ex: a limb) resulting in loss of a limb

Question 24

Why are Venous thrombi not as detrimental as Arterial thrombi?

Answer 24

If a vein is occluded, the blood going back to the heart will just take a different pathway. (In the same sense as a traffic jam and having to take an alternate route)

Question 25

Purple color on skin = _________?

Answer 25

Modeling (No oxygen to the area)