Chapter 114 Squamous Cel Carcinoma

Question 1

Excessive ______ appears to be related dmore to the development of SCC than to the development to BCC.

Answer 1

UV radiation

Question 2

Historically, SCC was associated with both ____ and ______.

Answer 2

burn scars and chronic ulcers

Question 3

SCCs have also been observed in _____, ______, ______, and _______.

Answer 3

transplanted skin, epidermal cyst, dental cyst and dermoid cyst.

Question 4

Recently, the _____, originally discovered in Merkel cell carcinoma, was identified in approximately 15% of cutaneous SCCs from immunocompetent patients.

Answer 4

MCPyV polyoma virus

Question 5

Apoptosis of keratinocytes that have sustained UV radiation-induced DNA damage, termed _______, requires the p53 tumor suppressor and represents a key protective mechanism against skin cancer

Answer 5

sunburn cell

Question 6

binds and targets p53 for rapid degradation

Answer 6

E6 protein encoded by oncogenic

Question 7

a firm, flesh-colored or erythematous, keratotic papule or plaque is most common

Answer 7

Squamous Cell Carcinoma Morphologies

Question 8

the vulva most commonly occurs on the anterior labia majora, beginning as a small warty nodule or an erosive erythematosus plaque.

Answer 8

Genital Squamous Cell Carcinoma

Question 9

decades after injury with skin breakdown and persistent erosion.

Answer 9

Scar Squamous cell Carcinoma

Question 10

rapid growth up to several centimeters in weeks, and then gradual involution over a period of months in most cases

Answer 10

Keratoacanthoma