Chapter 11: Muscle Tissue Flashcards
Characteristics of Muscle
Excitability Conductivity Contractility Extensibility Elasticity
Skeletal Muscle
Voluntary striated muscle attached to bone. Has light or dark bands called striatons.
Skeletal Muscle
Voluntary striated muscle attached to bone. Has light or dark bands called striatons.
Muscle cells are usually called muscle fibers because of their length
Sarcolemma
plasma membrane of a muscle fiber
Sarcoplasm
Muscle cytoplasm. Contains long proteins called myofibrils, glycogen, and myoglobin
Muscle Fibers are Multinuclear
Flattened nucleus pressed against inside of sarcolemma, as myoblasts fuse to produce each fiber in infants and each have a nucleus.
Some myelin remain as satellite cells between fiber and endomysium.
Smooth sarcoplasmic reticulum
Surrounds myofibrils. Mitochondria sit in spaces of myofibrils.
Myofilaments
Bundle of parallel proteins called myofilaments.
Thick Filaments: golf club. Made of hundreds of myosin.
Thin Filaments: 2 intertwined strands of fibrous actins. Each actin is like a beaded necklace, beads being globular (G) actin. Each G actin has an active site which binds to myosin. Tropomyosin blocks active site when muscle is relaxed. Tropomyosin has troponin attached to it.
Elastic Filaments: made of springing protein titin. Run through core thick filament and attach to M and Z ends.
Contractile Proteins
Myosin and Actin are contractile proteins because they do the work to shorten muscles.
Regulatory Proteins
Tropomyosin and Troponin because they determine which muscle should contract and which should not.
Dystrophin
Links actin filaments to proteins of the sarcolemma. When thin filaments move, dystrophin transfers force to basal lamina.
Striations
A (anisotropic) bands: dark, thick filaments lying side by side or overlapping.
H band: in middle of A band, thin filaments don’t reach.
M line: middle of H band
I band: Z bands anchor thin and elastic filaments, pulling in sarcolemma with shortening of cell.
Muscle Structure Hierarchy
- Muscle
- Fasicle
- Muscle Fiber
- Myofibril
- Sarcomere
- Myofilaments
Somatic Motor Neurons
Cell bodies are in the brain stem and spinal cord, with axons called somatic motor fibers which lead to muscle.
Motor Unit
One nerve fiber and all muscle fibers innervated by it. All stimulated and react at same time.
Small motor unit
More fine motor control, less strength. (hand, eye)
Large Motor Unit
More strength than control (quadriceps)
Synapse
When any nerve fiber meets target cells. When tagert cell is muscle fiber, synapse is called neuromuscular junction or motor end plate.
In synapse, nerve ends in swelling called axon terminal. Separated by target cell by synaptic cleft.
ACh (acetylcholine )
ACh in axon terminal, moves out of terminal by exocytosis, and enter synaptic cleft. Chemical messenger.
Deficiecy leads to muscle weakness or myasthenia gravis
Postsynaptic Membrane Folds
Folds with ACh receptors, increases surface area of ACh receptive membrane. Muscle nuclei underneath for synthesis of ACh