Chapter 11: Asymmetry Flashcards
What is Laterality?
the idea that the two cerebral hemispheres have separate functions
- laterality is not absolute but it is relevant meaning that both hemispheres are involved
There cerebral site is just as important as the what?
- cerebral side
- hemisphere/ side of the brain
Do animals exhibit laterality?
- yes a range of them do
- birds, rats, cats, monkeys
Do we act as though there is a single mind ?
- yes
- there is 2 hemispheres that specialize in different things but they act through one processor or mind
What are the anatomical asymmetry differences between the two hemispheres
Left
- producing and understanding language
- controlling movement on the right side of the body
- gyri and sulci mature more rapidly
- there is 1 heschl’s gyri (auditory cortex)
- there is a larger planum temporale/ wernickes
Right
- perceiving and synthesizing non-verbal information
- music, facial expression
- control movements on left side of body
- auditory cortex larger
- there is 2 heschls gyri (auditory cortex)
What are the 8 major anatomical asymmetry differences between the two hemispheres
- RH larger and heavier but LH contains more gray matter (neurons) relative to white matter (connections)
- LH larger planum temporale which provide anatomical basis for observed RH specialization in music and LH or language
- LH thalamus is dominant for language function and slightly larger in LH
- slope of lateral fissure less steep on LH, so the temporoparietal cortex appears larger in RH
- frontal operculum/ brocas is 1/3 larger surface on RH, but under surface larger in LH
- distribution of various NT
- RH extends more anteriorly and LH more posteriorly
- asymmetry patterns
What are the neuronal differences between the hemispheres
- the LH language areas have more dendritic branches which means more ability to enhance or suppress graded potentials
What are the 5 ways to study asymmetry in patients?
- brain stimulation
- double dissociation
- split-brain and commissurotomy patients
- Cartoid sodium amobardital injection
5.
What is Brain stimulation
- Wilder Penfields study
- this used on patients with epilepsy whose seizures were not controlled with medication
- this is done in conscious patients laying on right side with left side of brain exposed, EEG helps to identify source of seizures
- stimulate brain areas then observe patients behaviour/ responses
- the stimulation of the LH can block the ability to speak (ex telling a memory) , does not happen for the RH
- LH stimulation can accelerate speech production
- the RH stimulation can produce interpretive and experiential responses such as their interpretation of surroundings, such as deja vu or fear
What is Double Dissociaton
- two neocortical areas are functionally dissociated by 2 behavioural tests
- LH lesions in Rhanded patients produce language deficits that are not produced with RH lesions
Patients with a left temporal lobectomy shows what deficits
-deficits in memory and verbal IQ (specifically verbal recall)
(double dissociation studies)
Patients with a right temporal lobectomy showed what results?
- deficits in non-verbal recall, performance IQ, copy recall, memory quotient
- these scores continued to decrease over time
(double dissociation studies)
What are split-brain and Commissurotomy Patients
- epileptic seizures may begin in a restricted region of one hemisphere and progressively spread through the fibers of the corpus callosum to the homologous location in other hemisphere
- when medication failed, commissurotomy was the surgical procedure of disconnecting the two hemispheres
- william Van Wagnen 1940
- 200 million nerve fibers cut
- showed that hemispheres can function independently
Input from the left visual field goes where?
- visual input from the left visual field gets transferred from the left visual field to the right visual cortex via the corpus callosum
What happens when the LH of a split brain patient has access to information?
- it can initiate speech and hence communicate about information
- showed the RH was good at recognition abilities but poor at speech initiation because RH lacks access to the speech abilities in the RH
What happens when a split brain patient is shown an object in each visual field and asked to say what they see?
- when the LH (which can speak) sees the object in the Right visual fields the patient will respond correctly “ verbally answers I see blank object)
- but when the RH ( which cannot speak) sees the object in the Left visual field the patient replies with they see nothing
What is “ The Interpreter”
- when a split brain patient is presented with 2 pictures, 1 in each hemisphere and asked to select a third image that matches, each hand will choose differently
- when asked to explain their choice the patient will describe the image selected by the right hand, suggesting the only the LH is engaged in the interpretation of the situation
- RH specialized with facial recognition
How do split brain patients respond to the Chimeric Figures test
- a split brain patient will always choose the face presented in the left visual field (RH) suggesting specialization in facial recognition in patients
- when the patient sees a mismatched face they do not notice the difference because they are only seeing what is in that visual field