Chapter 10 R E V I E W Q U E S T I O N S

Question 1

1. The megakaryocyte progenitor that undergoes endomitosis is:

a. MK-I
b. BFU-Meg
c. CFU-Meg
d. LD-CFU-Meg

Answer 1

d. LD-CFU-Meg

Question 2

2. The growth factor that is produced in the kidney and induces growth and differentiation of committed megakaryocyte progenitors is:

a. IL-3
b. IL-6
c. IL-11
d. Thrombopoietin

Answer 2

d. Thrombopoietin

Question 3

3. What platelet organelle sequesters ionic calcium and binds a series of enzymes of the eicosanoid pathway?

a. Glycocalyx
b. Dense granules
c. Dense tubular system
d. Surface connected canalicular system

Answer 3

c. Dense tubular system

Question 4

4. What platelet membrane receptor binds fibrinogen and supports platelet aggregation?

a. GP Ib/IX/V
b. GP IIb/IIIa
c. GP Ia/IIa
d. P2Y1

Answer 4

b. GP IIb/IIIa

Question 5

5. What platelet membrane phospholipid flips from the inner surface to the plasma surface on activation and serves as the assembly point for coagulation factors?
   a. Phosphatidylethanolamine
   b. Phosphatidylinositol
   c. Phosphatidylcholine
   d. Phosphatidylserine

Answer 5

d. Phosphatidylserine

Question 6

6. What is the name of the eicosanoid metabolite produced from endothelial cells that suppresses platelet activity?

a. Thromboxane A2
b. Arachidonic acid
c. Cyclooxygenase
d. Prostacyclin

Answer 6

d. Prostacyclin

Question 7

7. Which of the following molecules is stored in platelet dense granules?

a. Serotonin
b. Fibrinogen
c. Platelet factor 4
d. Platelet-derived growth factor

Answer 7

a. Serotonin

Question 8

8. What plasma protein is essential for platelet adhesion?

a. VWF
b. Factor VIII
c. Fibrinogen
d. P-selectin

Answer 8

a. VWF

Question 9

9. Reticulated platelets can be enumerated in peripheral blood to detect:

a. Impaired platelet production in disease states
b. Abnormal organelles associated with diseases such as leukemia
c. Increased platelet production in response to need
d. Inadequate rates of membrane cholesterol exchange with the plasma

Answer 9

c. Increased platelet production in response to need

Question 10

10. White clots:

a. Occur primarily in the deep veins of the leg
b. Are characteristic of the secondary hemostatic process
c. Are largely composed of platelets and von Willebrand factor
d. Form normally in response to vascular injury and are completely harmless

Answer 10

c. Are largely composed of platelets and von Willebrand factor

Question 11

11. Upon activation, platelets secrete their alpha-granule contents via:

a. The dense tubule system
b. The surface connected canalicular system
c. The glycocalyx
d. Microtubules

Answer 11

b. The surface connected canalicular system

Question 12

12. Microparticles:

a. Are stored in platelet dense granules
b. Inhibit blood clotting
c. Bud off of platelets after their exposure to strong agonists
d. Exhibit no biologic activity

Answer 12

c. Bud off of platelets after their exposure to strong agonists