Chapt 23 Spirochetes

Question 0

Treponema pallidum pallidum sub-species?

Answer 0

Genital syphilis

Question 1

Chancre

Answer 1

Lesion characteristic of primary syphilis, typically a single, firm, painless erythematous ulcer with a clean surface & raised border

Question 2

Treponema pallidum pertenue sub-species?

Answer 2

Yaws

Question 3

Treponema pallidum indicum sub-species?

Answer 3

Non-venereal syphilis

Question 4

Stages of infection of T. pallidum?

Answer 4

Primary, Secondary, Latent, Tertiary

Question 5

Primary

Answer 5

Genital chancre (10-90 days)

Question 6

Secondary

Answer 6

Skin rashes (2-12 wks)

Question 7

Latent

Answer 7

Asymptomatic, but 50% untreated patients will progress

Question 8

Teritiary

Answer 8

Neurosyphilis (months-yrs after initial infection)

Question 9

Spirochetes

Answer 9

Elongated, slender, helical, “snake-like” bacteria, corkscrew locomotion, periplasmic flagella

Question 10

Treponema pallidum

Answer 10

Difficult to culture in vitro & rarely performed, Visual detection: Dark Field Microscopy & Direct Fluorescent Antibody Stains, Antibody dectection: Non-Treponemal Antigen Tests & Treponemal Antigen Tests, susceptible to penicillin

Question 11

Dark Field Microscopy

Answer 11

Observation of live motile organisms from lesions

Question 12

Direct Fluorescent Antibody Stains

Answer 12

Stains organsims from lesions

Question 13

Non-Treponemal Antigen tests

Answer 13

RPR & VDRL

Question 14

Treponemal Antigen tests

Answer 14

FTA & MHATP

Question 15

Borrelia

Answer 15

B. burgdorferi= causative agent of Lyme disease (originating from Lyme, Connecticut) spirochete with 3-10 loose coils, transmitted by bites of the Ixodes tick, symptoms: chills, fever, headache, skin rash, joint pains, other Borrelia species cause Relapsing Fever