Chap 10

Question 1

Different form of Vit E

Answer 1

1-Tocopherol 
      * alpha-tocopherol (3)
      *beta-tocopherol (3)
       * gama-tocopherol (3)
        * psy-tocopherol (3)
2- Same for Tocotrienol

Question 2

Mechanism of action of Vit E

Answer 2

Antiocidant

Provide electron to lipide radical

SEE SLIDE

Question 3

Function of Vit E

Answer 3

1- Function of alpha T as Antiocidant
Inhibit oxidation of LDL
Free radical scavenging in cancer cell, retina, brain,
2- Function of alpha-T &TT as cell signaling molecule
Modulate gene expression W/ anti-inflammatory, anti-proliferation, anti-apoptotic

Question 4

Interaction of Vit E with other nutrients

Regeneration of Vit E

Answer 4

Membrane, lipid droplets

Vit E cycle interact with Vit C cycle in aqueous environment

Question 5

Vit K
1- Discovery
2-Bioc or physio funct 
3-Deficiency syndrome or symptoms 
4- sources

Answer 5

1- Dam 1935
2- Active blood-clotting factors by gama- carboxylation get glutamic acid residue, carboxylate other proteins
3- Defective blood clotting
4- Syntheszed by intestinal bacteria, green leaky vegetables, soy bean, beef liver

Question 6

Vit K

Answer 6

Menadione K -4
Vit K1 — MK-4
Menaquinone-7 (MK-7)

Question 7

Mechanism of action of Vit K

Answer 7

Gla-protein bind to Ca2+, which reacts with other cell component like phospholipid to affect blood clotting and bone mineralization, among other process

Question 8

Vit K interact w/ other nutrients

- Excess Vit A & E interferes with Vit K absorption

Answer 8

• Excess Vit A & E interferes with Vit K absorption

Question 9

Vit K deficiency

Answer 9

-Unlikely on healthy adults
-Newborns at risk because milk is low in Vit K
-Severe deficiency— hemorrhage
Subclinical deficiency—– bone fragility

Question 10

Vit E
1- Discovery
2-Bioc or physio funct 
3-Deficiency syndrome or symptoms 
4- sources

Answer 10

1- Evan and Bishop 1923
2-Antiocidant
3-Myopathy, anemia, neuropathy
4- Vegetables seed