Challenges with drug types

Question 1

What 5 issues are there with small molecule drugs

Answer 1

1. Poor oral absorption
2. Insoluble
3. First pass metabolism
4. Drug resistance
5. Lack of specificity

Question 2

What issues are there with monoclonal antibodies

Answer 2

1. Immune reactions
2. Expensive and time consuming to make

Question 3

Give three examples of adverse immune reactions from mAbs

Answer 3

1. Infusion reactions
2. Cytokine storm
3. Anaphylaxis
4. Serum Sickness
5. Immunogenicity- inactivated by antibody in the body