Ch.9 Antimicrobial Chemotherapy

Question 1

__________ are agents used to treat disease. Most are antibiotics.

Answer 1

Chemotherapeutic agents

Question 2

Developed the concept of selective toxicity, identified dyes that effectively treated African sleeping sickness.

Answer 2

Paul Ehrlich

Question 3

Identified arsenic compounds that effectively treated syphilis.

Answer 3

Sahachiro Hato

Question 4

Discovered sulfonamides and sulfa drugs

Answer 4

Domagk, Jacques and Therese Trefouel

Question 5

Penicillin was discovered by __________ and _________.

Answer 5

Duchesne and Fleming

Question 6

The antiviral agent amantadine blocks viral _______ and _______.

Answer 6

Penetration and uncoating

Question 7

___________ inhibits neuraminidase and blocks the release of new viruses from the host cell.

Answer 7

Tamiflu

Question 8

Upon phosphorylation, the antiviral drug acyclovir inhibits viral ____________.

Answer 8

DNA polymerase

Question 9

The macrolide antibiotics are characterized by a ____________.

Answer 9

Lactone ring with one or more sugars attached

Question 10

Ampicillin and carbenicillin are both examples of _________ spectrum antibiotics.

Answer 10

Broad

Question 11

The aminoglycoside antibiotics are characterized by the presence of amino sugars and a ___________ __________.

Answer 11

Cyclohexane ring

Question 12

The ultimate result of penicillin treatment of sensitive bacteria resulting is cell-death resulting from _________ ___________.

Answer 12

Osmotic lysis

Question 13

True or false: The tetracyclines are bacteriostatic.

Answer 13

True

Question 14

Sulfonamides inhibit the growth of a wide variety of bacteria and are classified as _______ spectrum drugs.

Answer 14

Broad